INT156132

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 26
Total Number 29
Disease Relevance 14.33
Pain Relevance 3.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp9) transmembrane transport (Aqp9)
Anatomy Link Frequency
brain 7
astrocytes 4
spinal cord 2
tanycytes 1
liver 1
Aqp9 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 232 99.96 Very High Very High Very High
Spinal cord 165 99.68 Very High Very High Very High
depression 20 99.28 Very High Very High Very High
ischemia 40 98.76 Very High Very High Very High
Bile 7 98.32 Very High Very High Very High
Peripheral nervous system 116 98.16 Very High Very High Very High
Hippocampus 34 98.04 Very High Very High Very High
midbrain 23 90.68 High High
Neurotransmitter 39 84.84 Quite High
Pain 106 84.56 Quite High
Disease Link Frequency Relevance Heat
Cancer 174 99.98 Very High Very High Very High
Apoptosis 1328 99.64 Very High Very High Very High
Convulsion 22 99.40 Very High Very High Very High
Depression 20 99.28 Very High Very High Very High
Glioma 40 99.20 Very High Very High Very High
Glioblastoma 24 98.82 Very High Very High Very High
Cv Unclassified Under Development 32 98.76 Very High Very High Very High
Brain Disease 7 98.68 Very High Very High Very High
Lactic Acidosis 16 98.48 Very High Very High Very High
Pressure And Volume Under Development 192 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To date, only AQP1, AQP2, AQP4 and AQP9 have been found in the nervous system.
Gene_expression (found) of AQP9 in nervous system
1) Confidence 0.49 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19014999 Disease Relevance 0.21 Pain Relevance 0.17
Immunohistochemical staining also showed that AQP9 is present in tanycytes localized in the area lacking the blood–brain barrier such as the circumventricular organs of the third ventricle and hypothalamic regions, suggesting its possible role in the osmoreception [92].
Gene_expression (present) of AQP9 in third ventricle
2) Confidence 0.36 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.25 Pain Relevance 0.07
Astrocytes in the brain have been shown to express AQP9 whose expression levels are upregulated during ischemia [126] implicating a role in the regulation of postischemic edema in the brain [4].
Gene_expression (express) of AQP9 in brain associated with pressure and volume under development and ischemia
3) Confidence 0.36 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.26 Pain Relevance 0.05
Astrocytes in the brain have been shown to express AQP9 whose expression levels are upregulated during ischemia [126] implicating a role in the regulation of postischemic edema in the brain [4].
Gene_expression (expression) of AQP9 in brain associated with pressure and volume under development and ischemia
4) Confidence 0.36 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.26 Pain Relevance 0.05
In fact lactacystin induced apoptotic mouse cortical neurons showed extremely high expression levels for AQP8 and AQP9 (Fig. 1).
Gene_expression (expression) of AQP9 in neurons associated with apoptosis
5) Confidence 0.36 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.95 Pain Relevance 0
However this highly increased AQP9 expression was only observed in lactacystin induced apoptosis.
Gene_expression (expression) of AQP9 associated with apoptosis
6) Confidence 0.36 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.72 Pain Relevance 0
Stauros-porine (a broad spectrum kinase inhibitor)-mediated apoptosis showed downregulation of all AQP genes whereas although colchicines (inhibitor of microtubule polymerization)-mediated apoptosis showed a similar AQP gene profile when compared to that of lactacystin-mediated apoptosis, the increase in AQP9 expression was marginal (Fig. 2).


Gene_expression (expression) of AQP9 associated with apoptosis
7) Confidence 0.36 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.69 Pain Relevance 0
AQP9 is expressed in liver, white blood cells, testis and brain, and is involved in water and small solutes permeability [95].
Gene_expression (expressed) of AQP9 in brain
8) Confidence 0.35 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.58 Pain Relevance 0.05
In addition, AQP4 and AQP9 labeling on astrocytes was found in white matter tracts, hippocampus, septum, and hypothalamic nuclei including magnocellular nuclei [4].
Gene_expression (labeling) of AQP9 in white matter associated with hippocampus
9) Confidence 0.31 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.15 Pain Relevance 0.09
AQP4 is also present in these regions, suggesting that AQP9 contributes with AQP4 to the facilitation of water movements between CSF and brain parenchyma.
Gene_expression (contributes) of AQP9 in brain
10) Confidence 0.31 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.16 Pain Relevance 0.08
In contrast to AQP4, which is expressed primarily in the foot-processes of astrocytes, AQP9 is expressed throughout the astrocyte cell bodies and processes in the brain [5].
Gene_expression (expressed) of AQP9 in astrocytes
11) Confidence 0.31 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.23 Pain Relevance 0.07
In human astrocytic tumours AQP9 expression were both increased compared with normal brain tissue for all grades of astrocytic tumours and that expression was greater in high-grade tumours than in low-grade ones [94].
Gene_expression (expression) of AQP9 in brain associated with cancer
12) Confidence 0.31 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 1.46 Pain Relevance 0.08
In the brain, AQP9 is expressed in a subset of GFAP-positive ependymal cells lacking cilia, called tanycytes.
Gene_expression (expressed) of AQP9 in brain
13) Confidence 0.31 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.23 Pain Relevance 0.09
There are conflicting reports about AQP9 expression in the subset of ciliated ependymal cells [5, 22].
Gene_expression (expression) of AQP9 in ependymal cells
14) Confidence 0.31 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.06 Pain Relevance 0.06
Nevertheless, in human glioblastoma most glioma cells throughout the tumour revealed a strong AQP9 expression across the whole surface of the cells.
Gene_expression (expression) of AQP9 associated with cancer, glioblastoma and glioma
15) Confidence 0.31 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 1.43 Pain Relevance 0.08
AQP9 is also expressed in astrocytes of the glia limitans and white matter tracts.
Gene_expression (expressed) of AQP9 in astrocytes
16) Confidence 0.31 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.06 Pain Relevance 0.06
The increase of AQP9 expression may counteract the glioma-associated lactic acidosis by clearance of glycerol and lactate from the extracellular space and could be involved in the energy metabolism of the glioma [103].
Gene_expression (expression) of AQP9 associated with lactic acidosis and glioma
17) Confidence 0.31 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 1.60 Pain Relevance 0.07
Indeed, the presence of AQP9 in Xenopus Oocytes or proteoliposomes injected facilitated the diffusion of water, but also polyols (glycerol, mannitol, and sorbitol), purines (adenine), pyrimidines (uracil and chemotherapeutic agent 5-fluorouracil) and monocarboxylates (lactate, ?
Gene_expression (presence) of AQP9 in Oocytes
18) Confidence 0.31 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0 Pain Relevance 0
The expression of six isoforms of AQP protein (AQP1, 3, 4, 5, 8, 9) has been reported in the glial cells Table 1, being identified in astrocytes (AQP1, 3, 4, 5, 8, 9), oligodendrocytes (AQP8), tanycytes (AQP9) and ependymal cells (AQP1, 4, 9) [5, 40, 49, 52, 58, 63, 93].
Gene_expression (tanycytes) of AQP9 in tanycytes
19) Confidence 0.30 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.12 Pain Relevance 0.22
In addition, AQP1 expression in these may provide a membrane marker to distinguish these cells from glial cells of the CNS that express AQP4 and AQP9 [29].
Gene_expression (express) of AQP9 in glial cells associated with central nervous system
20) Confidence 0.27 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.45 Pain Relevance 0.37

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