INT156134

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Context Info
Confidence 0.59
First Reported 2009
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 7.20
Pain Relevance 5.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp1) transmembrane transporter activity (Aqp1) plasma membrane (Aqp1)
nucleus (Aqp1) transmembrane transport (Aqp1) cytoplasm (Aqp1)
Anatomy Link Frequency
spinal cords 4
neurons 3
trigeminal ganglia 2
Schwann cells 1
Aqp1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 36 99.84 Very High Very High Very High
Sciatic nerve 12 99.72 Very High Very High Very High
Eae 39 99.70 Very High Very High Very High
Migraine 164 99.44 Very High Very High Very High
Spinal cord 73 98.56 Very High Very High Very High
Dorsal horn 28 98.12 Very High Very High Very High
Pain 98 95.32 Very High Very High Very High
IPN 2 94.80 High High
anesthesia 3 92.88 High High
Peripheral nervous system 24 92.00 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 44 99.84 Very High Very High Very High
Inflammatory Pain 13 99.70 Very High Very High Very High
Headache 144 99.44 Very High Very High Very High
Injury 67 99.36 Very High Very High Very High
Contusions 3 99.32 Very High Very High Very High
Neuropathic Pain 50 98.44 Very High Very High Very High
Cyst 4 95.80 Very High Very High Very High
Pressure And Volume Under Development 23 95.44 Very High Very High Very High
Pain 107 95.32 Very High Very High Very High
Spinal Cord Injury 3 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unfortunately, the mechanisms that control AQP-1 gene expression in the CNS, under normal or pathological conditions, are still poorly understood.
Regulation (control) of Gene_expression (expression) of AQP-1 gene
1) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.53 Pain Relevance 0.17
Interestingly, various neuropathological conditions involve the up-regulation of AQP-1 expression in the CNS.
Regulation (regulation) of Gene_expression (expression) of AQP-1
2) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.62 Pain Relevance 0.23
Interestingly; AQP1 levels were not affected by long-lasting hypertonicity that significantly increased astrocytic AQP4, suggesting that the primary role of AQP1 is not regulating isotonicity in spinal cords.
Neg (not) Regulation (affected) of Gene_expression (levels) of AQP1 in spinal cords
3) Confidence 0.42 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.11 Pain Relevance 0.81
The AQP-1 expression remained unaltered in TG in a mice model of perioral acute inflammatory pain although the AQP-2 expression was remarkably increased in small-sized neurons and Schwann cells [56].
Regulation (unaltered) of Gene_expression (expression) of AQP-1 in neurons associated with eae and trigeminal ganglion
4) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 1.27 Pain Relevance 1.00
Apart from this, the AQP1 expression remained unaltered.
Regulation (unaltered) of Gene_expression (expression) of AQP1
5) Confidence 0.26 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19014999 Disease Relevance 0.26 Pain Relevance 0.36
In addition, another recent work based on a neuropathic rat model of chronic constriction injury (CCI) of sciatic nerve, reported no alteration of AQP1 expression both in dorsal root ganglia and in spinal cord [7].


Neg (no) Regulation (alteration) of Gene_expression (expression) of AQP1 in spinal cord associated with eae, injury, neuropathic pain, sciatic nerve and spinal cord
6) Confidence 0.25 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.04 Pain Relevance 0.78
Moreover, in a recent work in a mouse model of formalin trigeminal acute inflammatory pain, there are no alterations in AQP1 expression in trigeminal ganglia as reported in Fig. (1) [6].
Neg (no) Regulation (alterations) of Gene_expression (expression) of AQP1 in trigeminal ganglia associated with eae
7) Confidence 0.25 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.11 Pain Relevance 0.94
The AQP-1 expression remained unaltered in TG in a mice model of perioral acute inflammatory pain although the AQP-2 expression was remarkably increased in small-sized neurons and Schwann cells [56].
Regulation (unaltered) of in Schwann cells Gene_expression (expression) of AQP-1 in neurons associated with eae and trigeminal ganglion
8) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 1.27 Pain Relevance 1.00

General Comments

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