INT156137

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Context Info
Confidence 0.73
First Reported 2007
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 13.30
Pain Relevance 3.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a2) extracellular region (Col1a2) proteinaceous extracellular matrix (Col1a2)
protein binding, bridging (Col1a2)
Anatomy Link Frequency
fibroblasts 4
lung 2
stroma 1
ASM 1
cartilage 1
Col1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 382 100.00 Very High Very High Very High
chemokine 106 100.00 Very High Very High Very High
metalloproteinase 21 100.00 Very High Very High Very High
fibrosis 445 99.48 Very High Very High Very High
Chronic pancreatitis 39 99.32 Very High Very High Very High
Acupuncture 114 98.32 Very High Very High Very High
Inflammatory response 26 98.08 Very High Very High Very High
Arthritis 99 97.52 Very High Very High Very High
Snapping jaw 4 93.76 High High
Inflammatory marker 8 92.52 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 393 100.00 Very High Very High Very High
Stomach Cancer 58 99.84 Very High Very High Very High
Pulmonary Fibrosis 100 99.68 Very High Very High Very High
Disease 148 99.64 Very High Very High Very High
Immunization 26 99.56 Very High Very High Very High
Pancreatitis 57 99.32 Very High Very High Very High
Stress 62 99.04 Very High Very High Very High
Fibrosis 599 98.88 Very High Very High Very High
Asthma 117 98.78 Very High Very High Very High
Wound Healing 8 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After transfection of SPARC siRNA, the fibroblasts showed a decreased expression of Col1a2 that was originally over-expressed in the TBR1CA; Cre-ER mice (Figure 2).
Gene_expression (expression) of Col1a2 in fibroblasts
1) Confidence 0.73 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.33 Pain Relevance 0
On the other hand, much higher levels of gene expression of Col1A2 and Col3A1, and protein content of collagen were observed in bleomycin-induced lung tissues when they were compared to that in skin tissues (5.2-fold, 6.7-fold and 3.6-fold increase vs. 3.8-fold, 2.8-fold and 2.2-fold increase, respectively), which suggested that tissue damage and fibrosis in lung might be more severe than that in skin.
Gene_expression (expression) of Col1A2 in skin associated with fibrosis
2) Confidence 0.73 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.64 Pain Relevance 0.30
The changes of tissue fibrotic level further were confirmed with significantly decreased collagen gene expression (Figure 5A).
Gene_expression (expression) of collagen gene associated with fibrosis
3) Confidence 0.73 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.62 Pain Relevance 0.26
Genotyping of 15 SNPs in the VDR, CTR, IL-6, COL1A1, COL1A2, and LRP5 genes
Gene_expression (genes) of COL1A2
4) Confidence 0.64 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.21 Pain Relevance 0
In addition to collagen gene expression, the Ctgf and the SPARC expression were significantly or marginal significantly reduced by SPARC siRNA and Ctgf siRNA treatment, respectively (Figure 5B).
Gene_expression (expression) of collagen gene
5) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.12 Pain Relevance 0.03
As measured by quantitative real-time RT-PCR, the transcripts of Col1a2, Ctgf and SPARC showed increased expression in the fibroblasts from TBR1CA; Cre-ER mice injected with 4-OHT, in which Tgfbr1 was constitutively active, compared with those in the cells from TBR1CA; Cre-ER mice injected with oil (Figure 1).
Gene_expression (expression) of Col1a2 in fibroblasts
6) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0 Pain Relevance 0
Gene and protein expressions of the Col1a2 and the Ctgf were examined by real-time RT-PCR and Western blotting, respectively.
Spec (examined) Gene_expression (expressions) of Col1a2
7) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888211 Disease Relevance 0.52 Pain Relevance 0.08
Gene and protein expression of Col1a2, Ctgf and SPARC in the fibroblasts from TBR1CA; Cre-ER mice with and without transfection of siRNAs of SPARC or Ctgf
Gene_expression (expression) of Col1a2 in fibroblasts
8) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0 Pain Relevance 0
However, in Ctgf siRNA or SPARC siRNA treated mice skin that also received bleomycin injection, the expression of the Col1a2 and Col3a1 appeared to be normal in skin tissues (Figure 5A, P = 0.025 and 0.003 for each gene in Ctgf siRNA treatment, and P = 0.031 and 0.010 in SPARC siRNA treatment), and were significantly improved in lung tissues (about 2.7-fold reduction for Col1a2 and 1.9-fold reduction for Col3a1, compared to bleomyin-injected mice without siRNA treatment, P < 0.05 for both) (Figure 5B).
Gene_expression (expression) of Col1a2 in lung
9) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.08 Pain Relevance 0
1), connective tissue growth factor (CTGF), type I procollagen (COL1A2), vascular endothelial growth factor (VEGF) and 18S on the Applied Biosystems 7900 Prism® Sequence Detection System (Applied Biosytems, Foster City, CA).
Gene_expression (connective) of COL1A2 in connective tissue
10) Confidence 0.54 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 0.08 Pain Relevance 0.03
The Sircol™ Soluble Collagen Assay kit (Biocolor Ltd., Northern Ireland) was used to extract collagen from duplicate samples by using 100 ?
Gene_expression (extract) of collagen
11) Confidence 0.54 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 0.06 Pain Relevance 0.04
The Sircol™ Soluble Collagen Assay kit (Biocolor Ltd., Northern Ireland) was used to extract collagen from duplicate samples by using 100 ?
Gene_expression (extract) of Collagen
12) Confidence 0.54 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 0.06 Pain Relevance 0.04
1 has long been regarded as the most potent stimulator of collagen synthesis during lung fibrosis [33].
Gene_expression (synthesis) of collagen in lung associated with fibrosis and pulmonary fibrosis
13) Confidence 0.48 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 1.67 Pain Relevance 0.19
We confirmed significantly lower transcript levels of Col1a1, Col1a2, Col3a1 and Col4a1 in aged stroma by qRT-PCR (Figure 5A).
Gene_expression (levels) of Col1a2 in stroma
14) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.43 Pain Relevance 0.08
Consistently, the protein levels of collagen I and fibronectin were decreased in the Smad7 transgenic mice.
Gene_expression (levels) of collagen I associated with targeted disruption
15) Confidence 0.16 Published 2009 Journal Biochim. Biophys. Acta Section Abstract Doc Link 19015026 Disease Relevance 1.12 Pain Relevance 0.43
Expression of Sox9, Runx2, and Osterix was low, as was that of collagen II, collagen I, and aggrecan, thus altering the fibrocartilaginous nature of the condyle.
Gene_expression (Expression) of collagen II in condyle
16) Confidence 0.10 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20200412 Disease Relevance 0.26 Pain Relevance 0.32
Collagen I, III, V and VI were all expressed in the AIPC and CP group, although with different patterns and intensities.
Gene_expression (expressed) of Collagen I associated with chronic pancreatitis
17) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 0.80 Pain Relevance 0.45
1, presumably expressed mainly in macrophages, and collagen I, a major fibrogenic product expressed by myofibroblasts, in a TSA-treated healing cornea.
Gene_expression (expressed) of collagen I in cornea
18) Confidence 0.06 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.29 Pain Relevance 0.11
Effects of TSA on expression of inflammation-related growth factors or collagen I were examined by real-time RT–PCR or immunoassay in mouse macrophages or human subconjunctival fibroblasts.
Gene_expression (expression) of collagen I in fibroblasts associated with inflammation
19) Confidence 0.05 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC3013068 Disease Relevance 0.72 Pain Relevance 0.21
The transcription factor Sox9, which is associated with chondrogenic differentiation and collagen II synthesis, is expressed throughout the disc structures during embryogenesis (Barrionuevo et al., 2006) and in the newborn AF (Gruber et al., 2005).
Gene_expression (synthesis) of collagen II
20) Confidence 0.05 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.15 Pain Relevance 0

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