INT156138

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Context Info
Confidence 0.55
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.07
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a2) extracellular region (Col1a2) proteinaceous extracellular matrix (Col1a2)
protein binding, bridging (Col1a2)
Anatomy Link Frequency
fibroblasts 2
Col1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 73 98.88 Very High Very High Very High
Chronic pancreatitis 2 92.04 High High
Inflammation 18 82.48 Quite High
Inflammatory marker 2 27.04 Quite Low
Inflammatory response 2 16.00 Low Low
corticosteroid 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 15 99.44 Very High Very High Very High
Fibrosis 114 99.02 Very High Very High Very High
Pancreatitis 3 92.04 High High
INFLAMMATION 22 82.48 Quite High
Disease 17 67.12 Quite High
Systemic Sclerosis 20 5.00 Very Low Very Low Very Low
Pulmonary Fibrosis 16 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
Keloid Scars 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The changes of tissue fibrotic level further were confirmed with significantly decreased collagen gene expression (Figure 5A).
Negative_regulation (decreased) of Gene_expression (expression) of collagen gene associated with fibrosis
1) Confidence 0.55 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.62 Pain Relevance 0.26
After transfection of SPARC siRNA, the fibroblasts showed a decreased expression of Col1a2 that was originally over-expressed in the TBR1CA; Cre-ER mice (Figure 2).
Negative_regulation (decreased) of Gene_expression (expression) of Col1a2 in fibroblasts
2) Confidence 0.55 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.33 Pain Relevance 0
Consistently, the protein levels of collagen I and fibronectin were decreased in the Smad7 transgenic mice.
Negative_regulation (decreased) of Gene_expression (levels) of collagen I associated with targeted disruption
3) Confidence 0.11 Published 2009 Journal Biochim. Biophys. Acta Section Abstract Doc Link 19015026 Disease Relevance 1.12 Pain Relevance 0.43

General Comments

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