INT156148

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 9.98
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CTGF) Golgi apparatus (CTGF) cytosol (CTGF)
extracellular space (CTGF) extracellular region (CTGF) proteinaceous extracellular matrix (CTGF)
Anatomy Link Frequency
knees 4
macrophages 2
fibroblast 2
IVD 2
synovial cells 1
CTGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 42 97.80 Very High Very High Very High
fibrosis 4 95.36 Very High Very High Very High
Chronic low back pain 5 93.40 High High
Pain 10 90.48 High High
Inflammation 82 89.52 High High
Arthritis 4 72.24 Quite High
cytokine 28 58.16 Quite High
metalloproteinase 5 56.56 Quite High
agonist 12 47.72 Quite Low
corticosteroid 10 34.12 Quite Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 146 99.04 Very High Very High Very High
Airway Remodeling 6 98.88 Very High Very High Very High
Sprains And Strains 26 98.32 Very High Very High Very High
Cancer 201 98.20 Very High Very High Very High
Osteoarthritis 42 97.80 Very High Very High Very High
Infection 23 97.70 Very High Very High Very High
Intervertebral Disk Degeneration 5 96.84 Very High Very High Very High
Fibrosis 4 95.36 Very High Very High Very High
Low Back Pain 5 93.08 High High
Nicotine Addiction 31 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunohistochemical expression of CTGF was correlated with the degree of degeneration.
Gene_expression (expression) of CTGF
1) Confidence 0.78 Published 2008 Journal Biotech Histochem Section Abstract Doc Link 19016368 Disease Relevance 0.15 Pain Relevance 0.08
Our results showed that CTGF is expressed in non-degenerated and degenerated human IVDs and increased expression of CTGF is associated with degenerated discs, particularly within areas of neovascularization.
Gene_expression (expressed) of CTGF
2) Confidence 0.78 Published 2008 Journal Biotech Histochem Section Abstract Doc Link 19016368 Disease Relevance 0.15 Pain Relevance 0.07
Our results showed that CTGF is expressed in non-degenerated and degenerated human IVDs and increased expression of CTGF is associated with degenerated discs, particularly within areas of neovascularization.
Gene_expression (expression) of CTGF
3) Confidence 0.78 Published 2008 Journal Biotech Histochem Section Abstract Doc Link 19016368 Disease Relevance 0.14 Pain Relevance 0.07
To investigate the expression of CTGF in both normal and degenerated IVD, 21 IVDs were obtained from patients at surgery or postmortem examination and grouped according to the severity of histological degeneration.
Spec (investigate) Gene_expression (expression) of CTGF in IVD
4) Confidence 0.78 Published 2008 Journal Biotech Histochem Section Abstract Doc Link 19016368 Disease Relevance 0.16 Pain Relevance 0.09
Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro.
Gene_expression (expression) of CTGF in fibroblast associated with osteoarthritis
5) Confidence 0.75 Published 2010 Journal J. Orthop. Res. Section Title Doc Link 19890996 Disease Relevance 0.57 Pain Relevance 0.30
In this study, after human synovial cells were stimulated with HA and Hylan (Synvisc) for 24 h, real-time polymerase chain reaction (real-time PCR) was used to detect the alteration of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) gene expression, which were specific genes related to pathogenesis of OA knees.
Gene_expression (expression) of CTGF in knees associated with osteoarthritis
6) Confidence 0.75 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19890996 Disease Relevance 0.61 Pain Relevance 0.30
We suggested that the profile of CTGF, TGF-beta1, and VEGF gene expressions in our study might provide the rational mechanism for the therapeutic effect of hyaluronan on OA knees.
Gene_expression (expressions) of CTGF in knees associated with osteoarthritis
7) Confidence 0.75 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19890996 Disease Relevance 0.57 Pain Relevance 0.28
In this study, after human synovial cells were stimulated with HA and Hylan (Synvisc) for 24 h, real-time polymerase chain reaction (real-time PCR) was used to detect the alteration of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) gene expression, which were specific genes related to pathogenesis of OA knees.
Gene_expression (expression) of connective tissue growth factor in knees associated with osteoarthritis
8) Confidence 0.75 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19890996 Disease Relevance 0.61 Pain Relevance 0.31
The synovial cells with treatment of 0.1 mg/mL Hylan decreased the CTGF gene expression (0.66-fold) and VEGF (0.78-fold) compared to 0.1 mg/mL HA (alpha < 0.05).
Gene_expression (expression) of CTGF gene in synovial cells
9) Confidence 0.75 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19890996 Disease Relevance 0.51 Pain Relevance 0.28
Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro.
Gene_expression (expression) of connective tissue growth factor in fibroblast associated with osteoarthritis
10) Confidence 0.75 Published 2010 Journal J. Orthop. Res. Section Title Doc Link 19890996 Disease Relevance 0.57 Pain Relevance 0.29
Connective tissue growth factor expression in human intervertebral disc: implications for angiogenesis in intervertebral disc degeneration.
Gene_expression (expression) of tissue growth factor in intervertebral disc associated with intervertebral disk degeneration
11) Confidence 0.68 Published 2008 Journal Biotech Histochem Section Title Doc Link 19016368 Disease Relevance 0.19 Pain Relevance 0.09
We suggested that the profile of CTGF, TGF-beta1, and VEGF gene expressions in our study might provide the rational mechanism for the therapeutic effect of hyaluronan on OA knees.
Gene_expression (profile) of CTGF in knees associated with osteoarthritis
12) Confidence 0.65 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19890996 Disease Relevance 0.58 Pain Relevance 0.28
In particular, CTGF (connective tissue growth factor) was found to be secreted by macrophages at tumor sites.
Gene_expression (connective) of CTGF in macrophages associated with cancer
13) Confidence 0.42 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.27 Pain Relevance 0.14
Expression of at least two of these genes, CTGF and COL12A1, is controlled by mechanical strain.
Gene_expression (Expression) of CTGF associated with sprains and strains
14) Confidence 0.40 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2527292 Disease Relevance 0.24 Pain Relevance 0
Anti-sense 2’-O-methyl oligoribonucleotides targeting the miRNAs from this cluster caused partial restoration of Tsp1 and CTGF expression.
Gene_expression (expression) of CTGF
15) Confidence 0.40 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.71 Pain Relevance 0
In particular, CTGF (connective tissue growth factor) was found to be secreted by macrophages at tumor sites.
Gene_expression (connective) of tissue growth factor in macrophages associated with cancer
16) Confidence 0.37 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.29 Pain Relevance 0.14
Also, latent adenovirus E1A infection of epithelial cells could contribute to airway remodelling in COPD by the viral E1A gene, inducing TGF-beta 1 and CTGF expression and shifting cells towards a more mesenchymal phenotype[84].


Gene_expression (expression) of CTGF in epithelial cells associated with pulmonary disease, airway remodeling and infection
17) Confidence 0.12 Published 2004 Journal Respir Res Section Body Doc Link PMC533858 Disease Relevance 1.65 Pain Relevance 0.15

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