INT156169

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 2.84
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SMG1) nucleus (SMG1) response to stress (SMG1)
cytoplasm (SMG1)
Anatomy Link Frequency
covering 1
neurons 1
nerve 1
lip 1
palate 1
SMG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 5 100.00 Very High Very High Very High
Multiple sclerosis 3 98.08 Very High Very High Very High
Neuropathic pain 3 96.52 Very High Very High Very High
Pain 6 88.08 High High
qutenza 1 58.24 Quite High
depression 10 27.08 Quite Low
alcohol 14 5.00 Very Low Very Low Very Low
drug abuse 14 5.00 Very Low Very Low Very Low
headache 12 5.00 Very Low Very Low Very Low
Dopamine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cleft Palate 84 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 400 99.66 Very High Very High Very High
Disease 4 98.84 Very High Very High Very High
Cold Sores 4 98.16 Very High Very High Very High
Demyelinating Disease 3 98.08 Very High Very High Very High
Diabetes Mellitus 2 97.28 Very High Very High Very High
Obesity 3 96.88 Very High Very High Very High
Neuropathic Pain 3 96.52 Very High Very High Very High
Cancer 6 95.92 Very High Very High Very High
Pain 8 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, ATX has been linked to several additional human diseases including multiple sclerosis, diabetes, obesity, neuropathic pain, and Alzheimer's disease.
ATX Binding (linked) of associated with multiple sclerosis, diabetes mellitus, obesity, neuropathic pain and disease
1) Confidence 0.35 Published 2010 Journal Bioorg. Med. Chem. Section Abstract Doc Link 20005724 Disease Relevance 0.68 Pain Relevance 0.15
All six inhibitors were specific for ATX as they were without affect on two additional lipid preferring NPP isoforms.
ATX Binding (specific) of
2) Confidence 0.35 Published 2010 Journal Bioorg. Med. Chem. Section Abstract Doc Link 20005724 Disease Relevance 0.41 Pain Relevance 0.09
These two histidine residues appear to be important in ATX-substrate interaction.
ATX Binding (interaction) of
3) Confidence 0.21 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0 Pain Relevance 0
LIP activity departs from steady state shortly following the onset of the motion stimulus (time 0), integrating incoming motion information until a bound (dashed line) is reached.
LIP Binding (bound) of
4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824817 Disease Relevance 0 Pain Relevance 0
A decision would be reached when the accumulated signal in one pool of LIP neurons reaches the bound.
LIP Binding (bound) of in neurons
5) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824817 Disease Relevance 0 Pain Relevance 0
Either placebo or ATX were titrated upward after one week for three additional weeks.
ATX Binding (placebo) of
6) Confidence 0.12 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697545 Disease Relevance 0.47 Pain Relevance 0.06
For example, Adler and colleagues examined the quality of life in adults with ADHD following their treatment with ATX using a measure of health-related quality of life (HRQL; the Medical Outcomes Study 36-item short-form health survey [SF-36]).69 A well-recognized and validated instrument, it consists of 36 questions with a four-week recall covering eight health domains (subscales): physical functioning, bodily pain, role limitations due to physical problems, emotional problems, general health perceptions, mental health, social functioning, and vitality.
ATX Spec (examined) Binding (treatment) of in covering associated with mental disorders, pain and attention deficit hyperactivity disorder
7) Confidence 0.12 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697545 Disease Relevance 0.68 Pain Relevance 0.09
In a first of its kind survey, the authors have analyzed the management of cleft lip and palate in India.
lip Spec (analyzed) Binding (management) of in lip associated with cleft palate
8) Confidence 0.12 Published 2010 Journal Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India Section Body Doc Link PMC2938628 Disease Relevance 0.10 Pain Relevance 0
In a first of its kind survey, the authors have analyzed the management of cleft lip and palate in India.
lip Spec (analyzed) Binding (management) of in palate associated with cleft palate
9) Confidence 0.04 Published 2010 Journal Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India Section Body Doc Link PMC2938628 Disease Relevance 0.10 Pain Relevance 0
Interactions of nerve growth factor (NGF) and its receptor tropomyosin-related kinase (trkA) appear to be critical for maintaining HSV latency.
tropomyosin-related kinase Binding (Interactions) of in nerve associated with cold sores and nerve growth factor
10) Confidence 0.02 Published 2008 Journal J. Neurovirol. Section Abstract Doc Link 19016376 Disease Relevance 0.40 Pain Relevance 0.23

General Comments

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