INT156170

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.84
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (NFYC) nucleus (NFYC) intracellular (NFYC)
DNA binding (NFYC)
NFYC (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 207 99.04 Very High Very High Very High
Nicotine 42 93.20 High High
cytokine 12 84.16 Quite High
Nerve growth factor 5 79.52 Quite High
Anterior cingulate cortex 27 69.80 Quite High
amygdala 51 62.60 Quite High
alcohol 24 47.52 Quite Low
qutenza 1 32.24 Quite Low
imagery 18 5.00 Very Low Very Low Very Low
insula 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 465 100.00 Very High Very High Very High
Cold Sores 4 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 141 96.92 Very High Very High Very High
Impulse Control Disorders 54 94.24 High High
Herpes Simplex Virus 1 93.56 High High
Cognitive Disorder 19 65.80 Quite High
Drug Dependence 24 51.96 Quite High
Schizophrenia 3 34.56 Quite Low
Psychosis 3 33.20 Quite Low
Manic Depressive Disorder 3 29.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The HSM and the HC group were recruited through advertisements in newspapers.
HSM Binding (recruited) of associated with nicotine addiction
1) Confidence 0.21 Published 2010 Journal Addiction Biology Section Body Doc Link PMC3014110 Disease Relevance 1.15 Pain Relevance 0.18
HSM were included if they smoked at least 15 cigarettes per day, and did not engage in gambling activities more than twice a year.
HSM Neg (not) Binding (engage) of associated with nicotine addiction
2) Confidence 0.21 Published 2010 Journal Addiction Biology Section Body Doc Link PMC3014110 Disease Relevance 1.60 Pain Relevance 0.28
HSM were current smokers who engaged in an experimental smoking cessation as part of this study.
HSM Binding (engaged) of associated with nicotine addiction
3) Confidence 0.20 Published 2010 Journal Addiction Biology Section Body Doc Link PMC3014110 Disease Relevance 1.51 Pain Relevance 0.30
The HSV transactivator, VP16, which initiates the viral replicative cycle, binds HCF as do some other cellular proteins.
HSV transactivator Binding (binds) of associated with cold sores
4) Confidence 0.02 Published 2008 Journal J. Neurovirol. Section Abstract Doc Link 19016376 Disease Relevance 0.36 Pain Relevance 0.12
Tat

Tat is a virus-encoded transcriptional transactivator that binds to the RNA secondary structure encoded by the transactivation region (TAR) in the repeat segment of the LTR (+1 to +59) [215,216].

transactivator Binding (binds) of
5) Confidence 0.01 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.23 Pain Relevance 0.04

General Comments

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