INT156172

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Context Info
Confidence 0.72
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.19
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)
Anatomy Link Frequency
DRG 3
femoral artery 1
vessels 1
Trpv4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
member 8 2 100.00 Very High Very High Very High
dorsal root ganglion 12 50.00 Quite Low
Pain 6 5.00 Very Low Very Low Very Low
Calcium channel 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 14 99.60 Very High Very High Very High
Pain 6 83.36 Quite High
Ganglion Cysts 12 81.80 Quite High
Nociception 3 5.00 Very Low Very Low Very Low
Arterial Occlusive Diseases 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the aim of this study was to investigate the role of the shear stress sensitive Trpv4 in transmitting this physical stimulus into an active growth response. qRT-PCR at different time points during the growth of collateral vessels after femoral artery ligature (FAL) in rats showed a strong positive correlation of Trpv4 transcription and the intensity of FSS.
Transcription (transcription) of Trpv4 in femoral artery associated with stress
1) Confidence 0.72 Published 2009 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19017361 Disease Relevance 0.45 Pain Relevance 0.09
RESULTS: TRPV4 mRNA levels in DRG of mismatch and control groups were significantly higher (3.88- and 3.75-fold) than normal.
Transcription (levels) of TRPV4 in DRG
2) Confidence 0.71 Published 2010 Journal Neurol. Res. Section Body Doc Link 19278577 Disease Relevance 0.15 Pain Relevance 0
Real-time reverse transcription polymerase chain reaction and Western blot analysis were performed to assess the change of TRPV4 messenger RNA (mRNA) and protein expression in DRG.
Transcription (expression) of TRPV4 in DRG
3) Confidence 0.68 Published 2010 Journal Neurol. Res. Section Body Doc Link 19278577 Disease Relevance 0.17 Pain Relevance 0
CONCLUSION: TRPV4 is a key component in hypotonic signal transduction, and designed siRNA inhibits mRNA level, protein expression and function of TRPV4 in DRG neurons.
Transcription (expression) of TRPV4 in DRG
4) Confidence 0.68 Published 2010 Journal Neurol. Res. Section Body Doc Link 19278577 Disease Relevance 0 Pain Relevance 0
Micro array data of growing collateral vessels, exposed to chronically elevated fluid shear stress (FSS), showed increased transcription of the transient receptor potential cation channel, subfamily V, member 4 (Trpv4).
Transcription (transcription) of Trpv4 in vessels associated with stress and member 8
5) Confidence 0.63 Published 2009 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19017361 Disease Relevance 0.43 Pain Relevance 0.10

General Comments

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