INT156180

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 4.54
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SNRNP70) mRNA processing (SNRNP70) RNA binding (SNRNP70)
nucleus (SNRNP70)
Anatomy Link Frequency
outer layers 2
SNRNP70 (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 76 98.96 Very High Very High Very High
cINOD 6 97.12 Very High Very High Very High
Opioid 24 96.68 Very High Very High Very High
Morphine 7 95.40 Very High Very High Very High
member 8 1 88.72 High High
rheumatoid arthritis 38 79.92 Quite High
Pain 16 69.08 Quite High
Migraine 230 54.88 Quite High
diclofenac 1 42.60 Quite Low
algil 1 39.56 Quite Low
Disease Link Frequency Relevance Heat
Seborrhea 24 100.00 Very High Very High Very High
Renal Disease 61 98.72 Very High Very High Very High
Exfoliation Syndrome 69 97.96 Very High Very High Very High
Injury 16 97.48 Very High Very High Very High
Diabetes Mellitus 65 96.84 Very High Very High Very High
Burns 29 94.16 High High
Familial Combined Hyperlipidemia 254 93.56 High High
Proteinuria 18 89.16 High High
Rheumatoid Arthritis 41 79.92 Quite High
Pain 26 69.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, for these three SNPs, the GGT haplotype was overrepresented by 66% and constituted a major risk haplotype for XFS while the GAC haplotype was underrepresented by 83% and had the lowest associated risk in XFS patients.
Positive_regulation (overrepresented) of Gene_expression (overrepresented) of SNP associated with exfoliation syndrome
1) Confidence 0.49 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.71 Pain Relevance 0
Although our current study does not allow us to pinpoint which of these three USF1 SNPs in LD is the actual causative SNP, we were able to demonstrate that an allele-dependent effect of the rs3737787 tagged LD bin on downstream genes is mediated by USF1 and not the adjacent gene F11R.
Positive_regulation (causative) of Gene_expression (which) of SNP
2) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.69 Pain Relevance 0
Levels of SBD-2, SBD-3, SNP-1, and LL-37 increased, while SNP-1 and LL-37 showed increases in the externa, but LL-37 decreased significantly in the outer layers and the myenteric plexus following burn injury.
Positive_regulation (increased) of Gene_expression (Levels) of SNP-1 in outer layers associated with burns, injury and seborrhea
3) Confidence 0.37 Published 2010 Journal Eplasty Section Body Doc Link PMC2803769 Disease Relevance 0.98 Pain Relevance 0
CONCLUSIONS: These results suggest that OPRM1 gene tag SNP genotypes and haplotypes can primarily contribute to prediction of postoperative analgesic requirements in individual patients undergoing major open abdominal surgery.


Positive_regulation (contribute) of Gene_expression (genotypes) of SNP
4) Confidence 0.13 Published 2008 Journal Pharmacogenomics Section Body Doc Link 19018716 Disease Relevance 0 Pain Relevance 0
Resequencing KCNJ6 and SNP selection for the association study
Positive_regulation (Resequencing) of Gene_expression (selection) of SNP
5) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738941 Disease Relevance 0.40 Pain Relevance 1.82
Primers used for GRIA1 SNP rs2195450 were:
Positive_regulation (used) of Gene_expression (rs2195450) of SNP
6) Confidence 0.07 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.05 Pain Relevance 0.05
Primers used for GRIA1 SNP rs2195450 were:
Positive_regulation (for) of Gene_expression (rs2195450) of SNP
7) Confidence 0.07 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.05 Pain Relevance 0.05
Primers used for GRIA1 SNP rs548294 were:
Positive_regulation (for) of Gene_expression (used) of SNP
8) Confidence 0.07 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0 Pain Relevance 0
Primers used for GRIA1 SNP rs548294 were:
Positive_regulation (for) of Gene_expression (rs548294) of SNP
9) Confidence 0.07 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0 Pain Relevance 0
Primers used for GRIA3 SNP were:
Positive_regulation (for) of Gene_expression (used) of SNP
10) Confidence 0.07 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0 Pain Relevance 0
In this analysis, a SNP within ACACB showed the strongest association with diabetic nephropathy in Japanese patients with type 2 diabetes (rs2268388: intron 18 +4139 C > T, p?
Positive_regulation (within) of Gene_expression (showed) of SNP associated with diabetes mellitus and renal disease
11) Confidence 0.06 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2820513 Disease Relevance 0.68 Pain Relevance 0
Although our current study does not allow us to pinpoint which of these three USF1 SNPs in LD is the actual causative SNP, we were able to demonstrate that an allele-dependent effect of the rs3737787 tagged LD bin on downstream genes is mediated by USF1 and not the adjacent gene F11R.
Positive_regulation (causative) of Gene_expression (which) of SNP
12) Confidence 0.05 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.69 Pain Relevance 0
RFs analysis using genome-wide linkage SNP panel
Positive_regulation (linkage) of Gene_expression (panel) of SNP
13) Confidence 0.04 Published 2007 Journal BMC Proc Section Body Doc Link PMC2367463 Disease Relevance 0.28 Pain Relevance 0.11
0.05) of type I (PRKG1, also known as PGK) at 10q11, and the SNP rs8013938 (p?
Positive_regulation (as) of Gene_expression (rs8013938) of SNP
14) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0 Pain Relevance 0.09

General Comments

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