INT156189

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 2.81
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
cytoplasm (Ntrk1)
Anatomy Link Frequency
neurons 4
nociceptor 4
Sensory neurons 2
ACL 2
sympathetic 2
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 48 100.00 Very High Very High Very High
nociceptor 107 99.86 Very High Very High Very High
Neuropeptide 23 99.44 Very High Very High Very High
substance P 13 98.20 Very High Very High Very High
Congenital analgesia 2 96.00 Very High Very High Very High
Spinal cord 46 94.16 High High
Peripheral nervous system 8 93.68 High High
dorsal root ganglion 162 93.52 High High
Pain 13 92.12 High High
bDMF 49 86.08 High High
Disease Link Frequency Relevance Heat
Repression 13 100.00 Very High Very High Very High
Aging 5 99.42 Very High Very High Very High
Pain 15 96.00 Very High Very High Very High
Syndrome 2 94.64 High High
Ganglion Cysts 363 93.52 High High
Post Operative Pain 1 91.32 High High
Nociception 62 80.56 Quite High
Targeted Disruption 106 78.88 Quite High
Disease 131 71.92 Quite High
Apoptosis 148 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sensory neurons (nociceptors) that require NGF/trkA signaling for establishing and maintaining cutaneous innervation during development do not require NGF for central targeting [127].
Positive_regulation (require) of Gene_expression (/) of trkA in Sensory neurons associated with nerve growth factor and nociceptor
1) Confidence 0.49 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.13 Pain Relevance 0.35
One possible explanation is that the minimal enhancer of trkA, which Runx1 regulates [35], may not be required for the de novo induction of trkA expression [36].
Positive_regulation (induction) of Gene_expression (expression) of trkA
2) Confidence 0.40 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.59 Pain Relevance 0.27
On the other hand, Runx1 is essential for the late repression of trkA and induction of Ret when TrkA+ and Ret+ neurons segregate (Figure 1b) [34].
Positive_regulation (induction) of Gene_expression (essential) of trkA in neurons associated with repression
3) Confidence 0.40 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.66 Pain Relevance 0.28
Differential analysis of P0 WT versus P0 TrkA mutant mice libraries
Positive_regulation (versus) of Gene_expression (versus) of TrkA
4) Confidence 0.30 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0
Around the time of birth, nociceptors divide into 2 main populations, one of which maintains TrkA expression and secretes neuropeptides such as CGRP and substance P.
Positive_regulation (maintains) of Gene_expression (expression) of TrkA in nociceptors associated with nociceptor, neuropeptide and substance p
5) Confidence 0.28 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.24 Pain Relevance 0.67
Runx1 is initially co-expressed with TrkA in the nociceptor lineage [7,8], and initiation of TrkA expression is not dependent on Runx1 [48].
Neg (not) Positive_regulation (dependent) of Gene_expression (expression) of TrkA in nociceptor associated with nociceptor
6) Confidence 0.26 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.20 Pain Relevance 0.30
Indeed, in the mouse, from E14.5 to parturition, Runx1 expression is restricted to TrkA+ neurons, but by postnatal day 30, Runx1+ neurons are TrkA-negative and RET+ [26].
Positive_regulation (restricted) of Gene_expression (neurons) of TrkA in neurons
7) Confidence 0.26 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.53 Pain Relevance 0.31
In collaboration with the Runx1-induced ectopic expression of the growth factor receptors TrkA and RET, these extrinsic factors may significantly contribute to survival and possibly also to differentiation of the DOX-treated, transplanted bNCSCs.
Positive_regulation (induced) of Gene_expression (expression) of TrkA
8) Confidence 0.26 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0 Pain Relevance 0.25
In sympathetic neurons, ret expression is detected before trkA expression and appears correlated with trkC expression instead.
Positive_regulation (detected) of Gene_expression (expression) of trkA in sympathetic
9) Confidence 0.19 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.34
PATIENTS: 96 ASA physical status I, II, and III patients, scheduled for TKR or ACL reconstruction.
Positive_regulation (scheduled) of Gene_expression (reconstruction) of TKR in ACL
10) Confidence 0.07 Published 2008 Journal J Clin Anesth Section Body Doc Link 19019663 Disease Relevance 0.09 Pain Relevance 0
in aging might depend on a switch of TrkA-p75 expression and that p75 enhances A?
Positive_regulation (-) of Gene_expression (expression) of TrkA associated with aging
11) Confidence 0.06 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.37 Pain Relevance 0.11

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