INT156194

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.21
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GEM) plasma membrane (GEM) GTPase activity (GEM)
Anatomy Link Frequency
kidney 1
T cells 1
GEM (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 38 100.00 Very High Very High Very High
spinal inflammation 28 99.24 Very High Very High Very High
psoriasis 2 77.36 Quite High
Inflammation 15 57.88 Quite High
endometriosis 12 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 39 100.00 Very High Very High Very High
Low Back Pain 29 99.24 Very High Very High Very High
Toxicity 45 98.26 Very High Very High Very High
Disease 56 97.40 Very High Very High Very High
Autoimmune Disease 4 95.44 Very High Very High Very High
Sarcoma 1 85.76 High High
Mycobacterial Infection 1 85.68 High High
Systemic Sclerosis 1 84.44 Quite High
Solid Tumor 6 84.24 Quite High
Ovarian Cancer 47 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Low KIR expression on CD8+ T cells in RA might be associated with the mechanism of
KIR Spec (might) Binding (associated) of in T cells associated with rheumatoid arthritis
1) Confidence 0.20 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 1.36 Pain Relevance 0.46
OBJECTIVE: To investigate the association of killer cell immunoglobulin-like receptors (KIR) genotype and haplotype with ankylosing spondylitis (AS).
KIR Binding (association) of associated with spinal inflammation
2) Confidence 0.16 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 19489269 Disease Relevance 0.17 Pain Relevance 0.17
Upon our studies on the associations of KIR genes with a panel of autoimmune, gynecological, and neoplastic diseases as well as in the acute rejection of kidney graft, we observed effects of KIR2DS5 gene and HLA-C C1 and C2 groups in some of these clinical situations.
KIR Binding (associations) of in kidney associated with disease
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928722 Disease Relevance 0.36 Pain Relevance 0.10
Furthermore, a combination of GEM with the bevacizumab, an inhibitor of VEGF, in a phase III trial did not increase survival time [53].
GEM Binding (combination) of
4) Confidence 0.08 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.57 Pain Relevance 0
At this time, available data support the phase II-derived suggestions that in platinum-resistant disease none of the currently most frequently used drugs, such as PLD, GEM, or TPT, shows superiority over the others in terms of response rate and survival; in this context the 3-week schedule of administration of PLD at 40 mg/m2 seems to offer the most favorable toxicity profile, which is likely to sustain the achievement of better QoL scores, at least in comparison to GEM.110
GEM Binding (comparison) of associated with toxicity and disease
5) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952486 Disease Relevance 0.57 Pain Relevance 0
Interestingly, another component involved in MHC function, the natural killer-cell proteins that recognize MHC-peptide complexes (killer-cell immunoglobulin-like receptors, KIR), show signatures of balancing selection and coevolution with MHC class I [10]–[12].
KIR Spec (like) Binding (recognize) of
6) Confidence 0.07 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
OBJECTIVES: To assess the possible association of killer immunoglobulin-like receptor (KIR) genes, specifically KIR3DL1, KIR3DS1 and KIR3DL2, with ankylosing spondylitis (AS).
KIR Binding (association) of associated with spinal inflammation
7) Confidence 0.03 Published 2009 Journal Ann. Rheum. Dis. Section Abstract Doc Link 19019897 Disease Relevance 0.17 Pain Relevance 0.17

General Comments

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