INT156201

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 7.70
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTOR) Golgi apparatus (MTOR) endoplasmic reticulum (MTOR)
cytoplasm (MTOR) cytosol (MTOR) signal transduction (MTOR)
Anatomy Link Frequency
monocytes 3
Lymphocytes 2
muscle 2
polymorphonuclear leukocytes 1
MTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 20 87.68 High High
member 8 1 74.72 Quite High
chemokine 46 5.00 Very Low Very Low Very Low
Inflammation 32 5.00 Very Low Very Low Very Low
cytokine 16 5.00 Very Low Very Low Very Low
adenocard 16 5.00 Very Low Very Low Very Low
agonist 16 5.00 Very Low Very Low Very Low
Catecholamine 8 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Syndrome 104 99.62 Very High Very High Very High
Obstructive Sleep Apnea 146 98.56 Very High Very High Very High
Thrombosis 14 98.28 Very High Very High Very High
Insulin Resistance 18 98.04 Very High Very High Very High
Stomach Cancer 4 97.52 Very High Very High Very High
Pressure And Volume Under Development 10 94.96 High High
Carcinoma 14 94.48 High High
Glioblastoma 2 92.24 High High
Medulloblastoma 2 91.16 High High
Hypoxia 46 89.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that prolonged rapamycin treatment reduced the expression of total mTOR, which correlates with diminished levels of mTOR phosphorylation at Ser(2448) and Ser(2481).
Negative_regulation (reduced) of Gene_expression (expression) of mTOR
1) Confidence 0.58 Published 2009 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19019920 Disease Relevance 0.40 Pain Relevance 0.07
A reduced expression of mTOR may reflect an increased risk of vascular thrombosis.



Negative_regulation (reduced) of Gene_expression (expression) of mTOR associated with thrombosis
2) Confidence 0.38 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2940873 Disease Relevance 0.76 Pain Relevance 0
Lymphocytes of MetS patients showed a reduced mTOR expression (the mammalian target of rapamycin) which is a fundamental molecule of IS.
Negative_regulation (reduced) of Gene_expression (expression) of mTOR in Lymphocytes associated with metabolic syndrome
3) Confidence 0.38 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2940873 Disease Relevance 1.06 Pain Relevance 0
Together, these findings suggest that signaling through mTOR may decline transiently during the early response of human muscle to immobilization and may contribute to decreased mitochondrial gene expression, possibly through interactions with PGC-1?
Spec (may) Negative_regulation (decline) of Gene_expression (signaling) of mTOR in muscle
4) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.23 Pain Relevance 0
mammalian target of rapamycin (mTOR) pathway downstream of CXCR4 was shown to
Negative_regulation (shown) of Gene_expression (target) of mTOR
5) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.62 Pain Relevance 0.14
mammalian target of rapamycin (mTOR) pathway downstream of CXCR4 was shown to
Negative_regulation (downstream) of Gene_expression (target) of mTOR
6) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.61 Pain Relevance 0.14
We assessed the resting and n-formyl-methionyl-leucyl-phenylalanine (fMLP)- induced whole blood chemiluminescence (as a measure of oxidant production by polymorphonuclear leukocytes and monocytes), ferric reducing ability of plasma (FRAP) and H2O2 generation in the whole blood of 27 untreated OSAS patients, 22 subjects after a night of CPAP therapy and 11 controls without OSAS.
Negative_regulation (reducing) of Gene_expression (generation) of FRAP in monocytes associated with obstructive sleep apnea
7) Confidence 0.15 Published 2008 Journal J Negat Results Biomed Section Abstract Doc Link PMC2607253 Disease Relevance 1.01 Pain Relevance 0
We assessed the resting and n-formyl-methionyl-leucyl-phenylalanine (fMLP)- induced whole blood chemiluminescence (as a measure of oxidant production by polymorphonuclear leukocytes and monocytes), ferric reducing ability of plasma (FRAP) and H2O2 generation in the whole blood of 27 untreated OSAS patients, 22 subjects after a night of CPAP therapy and 11 controls without OSAS.
Negative_regulation (reducing) of in polymorphonuclear leukocytes Gene_expression (generation) of FRAP in monocytes associated with obstructive sleep apnea
8) Confidence 0.05 Published 2008 Journal J Negat Results Biomed Section Abstract Doc Link PMC2607253 Disease Relevance 1.01 Pain Relevance 0

General Comments

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