INT156204

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Context Info
Confidence 0.82
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 3.99
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTOR) Golgi apparatus (MTOR) endoplasmic reticulum (MTOR)
cytoplasm (MTOR) cytosol (MTOR) signal transduction (MTOR)
Anatomy Link Frequency
Hair 1
skin 1
MTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
positron emission tomography 8 87.92 High High
antagonist 5 80.72 Quite High
member 8 1 79.92 Quite High
Inflammation 17 10.32 Low Low
imagery 17 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
Spinal cord 10 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
headache 8 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 142 100.00 Very High Very High Very High
Insulin Resistance 30 96.52 Very High Very High Very High
Muscular Atrophy 252 96.28 Very High Very High Very High
Non-small-cell Lung Cancer 19 95.68 Very High Very High Very High
Stress 37 94.88 High High
Hypoxia 3 94.60 High High
Apoptosis 26 88.24 High High
Focal Segmental Glomerulosclerosis 1 85.08 High High
Hyperinsulinism 15 83.36 Quite High
Disease 44 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that prolonged rapamycin treatment reduced the expression of total mTOR, which correlates with diminished levels of mTOR phosphorylation at Ser(2448) and Ser(2481).
Phosphorylation (phosphorylation) of mTOR
1) Confidence 0.82 Published 2009 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19019920 Disease Relevance 0.39 Pain Relevance 0.08
The PI3K-AKT-mTOR pathway is dys-regulated in many cancers.16 In response to extracellular stimuli, PI3K phosphorylates the 3?
Phosphorylation (phosphorylates) of mTOR associated with cancer
2) Confidence 0.76 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.88 Pain Relevance 0
Another study, however, failed to detect any significant changes in the phosphorylation of Akt, mTOR, p70S6K, eEF2, eIF4E, and TSC2 in men following 10 and 21 d of ULS [26].
Phosphorylation (phosphorylation) of mTOR
3) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.21 Pain Relevance 0
Our results highlight the importance of mitochondrial down-regulation, decreased mTOR phosphorylation, and increased protein ubiquitination during the early phases of the muscular response to immobilization in humans.
Phosphorylation (phosphorylation) of mTOR
4) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.10 Pain Relevance 0
Phospho-mTOR, mTOR (rabbit monoclonal, Cell Signaling, Danvers, MA), Ub (rabbit polyclonal, Biomol, Plymouth Meeting, PA), CS (rabbit polyclonal, a kind gift from Dr.
Phosphorylation (Phospho) of mTOR
5) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0 Pain Relevance 0
Phospho-mTOR, mTOR (rabbit monoclonal, Cell Signaling, Danvers, MA), Ub (rabbit polyclonal, Biomol, Plymouth Meeting, PA), CS (rabbit polyclonal, a kind gift from Dr.
Phosphorylation (Phospho) of mTOR
6) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0 Pain Relevance 0
Hair, skin, and tumor biopsies showed decreased phosphorylation of many products downstream from the PI3K/mTOR pathway inhibited by XL765.
Phosphorylation (phosphorylation) of mTOR in skin associated with cancer
7) Confidence 0.60 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.55 Pain Relevance 0.04
Lastly, mTOR phosphorylation decreased significantly following 48 H of immobilization but not 14 D.


Phosphorylation (phosphorylation) of mTOR
8) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.35 Pain Relevance 0
In this study, both overfeeding diets induced significant increases in phosphorylation of mTOR and S6K1, yet only HF overfeeding was associated with increased serine phosphorylation of IRS-1.
Phosphorylation (phosphorylation) of mTOR
9) Confidence 0.47 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.23 Pain Relevance 0
Although this pattern was not seen for the changes in phosphorylation of mTOR, 4E-BP1, and GSK-3?
Phosphorylation (phosphorylation) of mTOR
10) Confidence 0.38 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
The phosphorylation of PKB Ser473 and p70S6k Thr389 increased concomitantly with insulin, but whereas raising insulin to 30 mU/l increased the phosphorylation of mTOR Ser2448, 4E-BP1 Thr37/46, or GSK3?
Phosphorylation (phosphorylation) of mTOR
11) Confidence 0.38 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Abstract Doc Link PMC2536736 Disease Relevance 0.08 Pain Relevance 0
However, there was a significant increase in phosphorylated mTOR resulting in increased phosphorylation of S6K1 following both overfeeding diets (Figure 4).


Phosphorylation (phosphorylated) of mTOR
12) Confidence 0.36 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0 Pain Relevance 0
When BCAA are administered during and after resistance exercise, phosphorylation of the mammalian target of rapamycin (mTOR) leads to a sequence of (anabolic) enzymatic activations that are not seen to equal extent when BCAA are withheld [23].
Phosphorylation (phosphorylation) of mTOR
13) Confidence 0.34 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129153 Disease Relevance 0 Pain Relevance 0
reduce the phosphorylation of Akt, an upstream positive modulator of mTOR, and
Phosphorylation (phosphorylation) of mTOR
14) Confidence 0.26 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220082 Disease Relevance 0.66 Pain Relevance 0.04
Hair, skin, and tumor biopsies showed decreased phosphorylation of many products downstream from the PI3K/mTOR pathway inhibited by XL765.
Phosphorylation (phosphorylation) of mTOR in Hair associated with cancer
15) Confidence 0.20 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.55 Pain Relevance 0.04

General Comments

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