INT156207

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.33
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTOR) Golgi apparatus (MTOR) endoplasmic reticulum (MTOR)
cytoplasm (MTOR) cytosol (MTOR) signal transduction (MTOR)
Anatomy Link Frequency
skin 3
Hair 1
MTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
positron emission tomography 8 87.92 High High
member 8 2 79.92 Quite High
headache 8 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
peripheral neuropathy 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 76 99.66 Very High Very High Very High
Muscular Atrophy 100 96.68 Very High Very High Very High
Focal Segmental Glomerulosclerosis 2 85.92 High High
Disease 30 83.08 Quite High
Proteinuria 8 81.48 Quite High
Nicotine Addiction 2 69.36 Quite High
Gastrointestinal Neoplasms 2 68.40 Quite High
Adhesions 8 67.76 Quite High
Toxicity 16 55.56 Quite High
Obesity 2 53.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that prolonged rapamycin treatment reduced the expression of total mTOR, which correlates with diminished levels of mTOR phosphorylation at Ser(2448) and Ser(2481).
Negative_regulation (diminished) of Phosphorylation (phosphorylation) of mTOR
1) Confidence 0.58 Published 2009 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19019920 Disease Relevance 0.39 Pain Relevance 0.08
Our results highlight the importance of mitochondrial down-regulation, decreased mTOR phosphorylation, and increased protein ubiquitination during the early phases of the muscular response to immobilization in humans.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of mTOR
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.10 Pain Relevance 0
We found that prolonged rapamycin treatment reduced the expression of total mTOR, which correlates with diminished levels of mTOR phosphorylation at Ser(2448) and Ser(2481).
Negative_regulation (levels) of Phosphorylation (phosphorylation) of mTOR
3) Confidence 0.43 Published 2009 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19019920 Disease Relevance 0.39 Pain Relevance 0.08
Lastly, mTOR phosphorylation decreased significantly following 48 H of immobilization but not 14 D.


Negative_regulation (decreased) of Phosphorylation (phosphorylation) of mTOR
4) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.35 Pain Relevance 0
Hair, skin, and tumor biopsies showed decreased phosphorylation of many products downstream from the PI3K/mTOR pathway inhibited by XL765.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of mTOR in skin associated with cancer
5) Confidence 0.31 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.55 Pain Relevance 0.04
Hair, skin, and tumor biopsies showed decreased phosphorylation of many products downstream from the PI3K/mTOR pathway inhibited by XL765.
Negative_regulation (decreased) of in Hair Phosphorylation (phosphorylation) of mTOR in skin associated with cancer
6) Confidence 0.11 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.55 Pain Relevance 0.04

General Comments

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