INT15622

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Context Info
Confidence 0.46
First Reported 1984
Last Reported 2003
Negated 0
Speculated 3
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 1.13
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
MBH 2
follicle 2
SK-N-SH 2
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 7 100.00 Very High Very High Very High
Delta opioid receptors 4 99.90 Very High Very High Very High
Endogenous opioid 5 99.74 Very High Very High Very High
opiate 5 99.16 Very High Very High Very High
narcan 18 96.84 Very High Very High Very High
Opioid 2 95.44 Very High Very High Very High
opioid receptor 3 95.00 High High
Dopamine 2 92.44 High High
antagonist 3 80.88 Quite High
Disease Link Frequency Relevance Heat
Stress 6 97.96 Very High Very High Very High
Reprotox - General 1 9 96.92 Very High Very High Very High
Cancer 2 87.64 High High
Galactorrhea 4 78.68 Quite High
Neuroblastoma 1 76.84 Quite High
Unwanted Pregnancy 1 25.00 Low Low
Pituitary Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone (500 micrograms), however, induced a twofold increase in LH levels within 15 min suggesting that an enhanced opiate rather than dopaminergic activity may be responsible for the suppression of GnRH and hence gonadotrophin secretion during suckling.
Spec (may) Positive_regulation (responsible) of Negative_regulation (suppression) of GnRH associated with narcan and opiate
1) Confidence 0.46 Published 1984 Journal J. Endocrinol. Section Abstract Doc Link 6420492 Disease Relevance 0 Pain Relevance 0.41
The results of this study imply that (1) delta opioid receptors may mediate the inhibitory effect of lower concentrations of morphine on LHRH levels in SK-N-SH cells, and (2) inhibition of LHRH level by high concentrations of morphine may involve systems other than opioid receptors.
Spec (may) Positive_regulation (mediate) of Negative_regulation (effect) of LHRH in SK-N-SH associated with opioid receptor, delta opioid receptors and morphine
2) Confidence 0.46 Published 2003 Journal Neuropeptides Section Abstract Doc Link 14607103 Disease Relevance 0.08 Pain Relevance 0.94
Chronic restraint also induced a decrease in hypothalamic LH-releasing hormone (LHRH) content in saline-treated rats.
Positive_regulation (induced) of Negative_regulation (decrease) of LHRH
3) Confidence 0.40 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1749459 Disease Relevance 0.33 Pain Relevance 0.39
Castration caused a 57% depletion of MBH LHRH in N rats; in castrated H rats the MBH LHRH content was also reduced by 40%, a significantly lesser extent.
Positive_regulation (caused) of Negative_regulation (depletion) of MBH LHRH in MBH
4) Confidence 0.40 Published 1987 Journal Endocrinology Section Abstract Doc Link 3297642 Disease Relevance 0.39 Pain Relevance 0.04
The present study investigates the possible role of endogenous opioid peptides in mediating the inhibitory effect of corticotropin-releasing factor (CRF) on circulating luteinizing hormone (LH).
Spec (investigates) Positive_regulation (mediating) of Negative_regulation (effect) of luteinizing hormone associated with endogenous opioid
5) Confidence 0.19 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2893271 Disease Relevance 0 Pain Relevance 0.35
Suckling induces a reduction in gonadotropin releasing hormone, luteinizing hormone and follicle stimulating hormone release, resulting in amenorrhea, through an intracerebral opioid pathway: beta-endorphins inhibit gonadotropin releasing hormone and dopamine secretions, which, in turn stimulates prolactin secretion and milk production.
Positive_regulation (induces) of Negative_regulation (reduction) of releasing hormone in follicle associated with dopamine, opioid and reprotox - general 1
6) Confidence 0.02 Published 1997 Journal Eur J Contracept Reprod Health Care Section Abstract Doc Link 9678098 Disease Relevance 0.33 Pain Relevance 0.14

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