INT156229

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.69
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfsf14) extracellular region (Tnfsf14) plasma membrane (Tnfsf14)
Anatomy Link Frequency
endothelial cells 2
macrophages 1
monocyte 1
Tnfsf14 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 35 99.98 Very High Very High Very High
chemokine 4 98.46 Very High Very High Very High
cytokine 5 94.84 High High
Angina 4 86.56 High High
imagery 23 76.80 Quite High
cva 4 66.08 Quite High
Inflammatory response 2 43.04 Quite Low
addiction 2 23.84 Low Low
ischemia 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 33 99.98 Very High Very High Very High
Atherosclerotic Plaque 4 98.94 Very High Very High Very High
Atherosclerosis 20 97.96 Very High Very High Very High
Cerebral Malaria 76 94.80 High High
Infection 23 92.96 High High
Cancer 8 88.52 High High
Necrosis 8 88.28 High High
Cv General 3 Under Development 4 86.56 High High
Vasculitis 4 85.32 High High
Disease 7 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis.
LIGHT Binding (interaction) of in endothelial cells associated with inflammation and atherosclerosis
1) Confidence 0.23 Published 2009 Journal Circ. Res. Section Title Doc Link 19023130 Disease Relevance 1.07 Pain Relevance 0.34
We also found that LIGHT acted synergistically with PAR-2 activation to promote enhanced release of the proatherogenic chemokines interleukin-8 and monocyte chemoattractant protein-1, underscoring that the interaction between LIGHT and PAR-2 is biologically active, promoting potent inflammatory effects.
LIGHT Binding (interaction) of in monocyte associated with chemokine and inflammation
2) Confidence 0.17 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19023130 Disease Relevance 1.10 Pain Relevance 0.40
We also found that LIGHT, LIGHT receptors, and PAR-2 showed enhanced expression, and, to some degree, colocalization in endothelial cells and macrophages, in the atherosclerotic plaques of ApoE(-/-) mice, suggesting that the inflammatory interaction between LIGHT and PAR-2 also may be operating in vivo within an atherosclerotic lesion.
LIGHT Binding (interaction) of in macrophages associated with atherosclerotic plaque, inflammation and atherosclerosis
3) Confidence 0.17 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19023130 Disease Relevance 0.88 Pain Relevance 0.34
We also found that LIGHT, LIGHT receptors, and PAR-2 showed enhanced expression, and, to some degree, colocalization in endothelial cells and macrophages, in the atherosclerotic plaques of ApoE(-/-) mice, suggesting that the inflammatory interaction between LIGHT and PAR-2 also may be operating in vivo within an atherosclerotic lesion.
LIGHT Binding (interaction) of in endothelial cells associated with atherosclerotic plaque, inflammation and atherosclerosis
4) Confidence 0.06 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19023130 Disease Relevance 0.88 Pain Relevance 0.34
Here, LIGHT, another LT?
LIGHT Binding (Here) of
5) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442868 Disease Relevance 0.77 Pain Relevance 0.18

General Comments

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