INT156231

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.78
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2r) plasma membrane (F2r) signal transducer activity (F2r)
Anatomy Link Frequency
urinary bladder 3
neuronal 1
endothelial cells 1
F2r (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 401 99.98 Very High Very High Very High
cytokine 12 96.20 Very High Very High Very High
substance P 89 87.84 High High
Hyperalgesia 7 83.72 Quite High
Pain 20 83.04 Quite High
chemokine 1 73.32 Quite High
agonist 41 62.24 Quite High
Inflammatory stimuli 38 53.76 Quite High
Inflammatory response 53 52.24 Quite High
Angina 1 50.36 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 491 99.98 Very High Very High Very High
Atherosclerosis 5 98.28 Very High Very High Very High
Cancer 51 89.88 High High
Necrosis 2 89.64 High High
Apoptosis 10 87.28 High High
Vasculitis 2 85.36 High High
Death 10 84.80 Quite High
Hyperalgesia 7 83.72 Quite High
Pain 20 83.04 Quite High
Coagulation Disorder 4 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Primary functions associated with PAR1-dependent genes (Figure 3 and 4)
PAR1 Binding (associated) of
1) Confidence 0.23 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.56 Pain Relevance 0.06
In addition, the use of curated networks such as the Ingenuity Pathways Analysis leads to a comprehensive integration of how PAR1-dependent transcripts correlate with canonical pathways and known biological functions.
PAR1 Binding (integration) of
2) Confidence 0.23 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.40 Pain Relevance 0.20
Development of the observed interactome of PAR1-specific genes
PAR1 Binding (interactome) of
3) Confidence 0.23 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.06 Pain Relevance 0.14
Although thrombin is a recognized physiological activator of PAR1 and PAR4, the endogenous enzymes responsible for activating PAR2 in urinary bladder are not known.
PAR1 Binding (recognized) of in urinary bladder
4) Confidence 0.23 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.43 Pain Relevance 0.25
Of note, a particular set of genes such as dctn1 and arf6 are involved in PAR trafficking, and their function is associated with other PAR1-dependent transcripts with function in the cytoskeleton reorganization.


PAR1 Binding (associated) of
5) Confidence 0.23 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0 Pain Relevance 0.03
Although thrombin is a recognized physiological activator of PAR1 and PAR4, the endogenous enzymes responsible for activating PAR2 in urinary bladder are not known.
PAR1 Binding (recognized) of in urinary bladder
6) Confidence 0.23 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.44 Pain Relevance 0.23
Although thrombin is a recognized physiological activator of PAR1 and PAR4, the endogenous enzymes responsible for activating PAR2 in urinary bladder are not known.
PAR1 Binding (recognized) of in urinary bladder
7) Confidence 0.21 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.31 Pain Relevance 0.11
Signal intensity for PAR1, PAR2 and PAR4 was determined by dividing grain counts by the area of the neuronal profile.
PAR1 Binding (intensity) of in neuronal
8) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.05 Pain Relevance 0
Thrombin or a specific PAR1 or PAR4 activating peptide (PAR1/4-AP) caused functional effects characteristic of activation of the PLC?
PAR1 Binding (specific) of
9) Confidence 0.20 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2956715 Disease Relevance 0.39 Pain Relevance 0.17
Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis.
proteinase-activated receptor Binding (interaction) of in endothelial cells associated with inflammation and atherosclerosis
10) Confidence 0.06 Published 2009 Journal Circ. Res. Section Title Doc Link 19023130 Disease Relevance 1.14 Pain Relevance 0.40

General Comments

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