INT156238

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Context Info
Confidence 0.08
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 2.85
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2rl1, Tnfsf14) extracellular space (Tnfsf14) signal transduction (F2rl1)
extracellular region (Tnfsf14) signal transducer activity (F2rl1)
Anatomy Link Frequency
macrophages 1
endothelial cells 1
monocyte 1
F2rl1 (Mus musculus)
Tnfsf14 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 24 99.98 Very High Very High Very High
chemokine 3 98.46 Very High Very High Very High
Angina 3 86.56 High High
cytokine 3 74.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 21 99.98 Very High Very High Very High
Atherosclerotic Plaque 3 98.94 Very High Very High Very High
Atherosclerosis 15 98.36 Very High Very High Very High
Cv General 3 Under Development 3 86.56 High High
Vasculitis 3 85.32 High High
Necrosis 6 82.64 Quite High
Cancer 6 82.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also found that LIGHT acted synergistically with PAR-2 activation to promote enhanced release of the proatherogenic chemokines interleukin-8 and monocyte chemoattractant protein-1, underscoring that the interaction between LIGHT and PAR-2 is biologically active, promoting potent inflammatory effects.
PAR-2 Binding (interaction) of LIGHT in monocyte associated with chemokine and inflammation
1) Confidence 0.08 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19023130 Disease Relevance 1.10 Pain Relevance 0.40
We also found that LIGHT, LIGHT receptors, and PAR-2 showed enhanced expression, and, to some degree, colocalization in endothelial cells and macrophages, in the atherosclerotic plaques of ApoE(-/-) mice, suggesting that the inflammatory interaction between LIGHT and PAR-2 also may be operating in vivo within an atherosclerotic lesion.
PAR-2 Binding (interaction) of LIGHT in macrophages associated with atherosclerotic plaque, inflammation and atherosclerosis
2) Confidence 0.08 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19023130 Disease Relevance 0.88 Pain Relevance 0.34
We also found that LIGHT, LIGHT receptors, and PAR-2 showed enhanced expression, and, to some degree, colocalization in endothelial cells and macrophages, in the atherosclerotic plaques of ApoE(-/-) mice, suggesting that the inflammatory interaction between LIGHT and PAR-2 also may be operating in vivo within an atherosclerotic lesion.
PAR-2 Binding (interaction) of LIGHT in endothelial cells associated with atherosclerotic plaque, inflammation and atherosclerosis
3) Confidence 0.03 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19023130 Disease Relevance 0.88 Pain Relevance 0.34

General Comments

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