INT156246

Context Info Confidence 0.17 First Reported 2009 Last Reported 2009 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.35 Pain Relevance 0.54

signal transduction (NFKB1, TNF) nucleoplasm (NFKB1) mitochondrion (NFKB1) intracellular (TNF) extracellular matrix organization (TNF) cytoplasm (NFKB1)

Anatomy Link Frequency microglia 2 NFKB1 (Homo sapiens) TNF (Homo sapiens)

Pain Link Frequency Relevance Heat Morphine 9 99.84 Inflammation 1 89.64 cytokine 2 86.48 narcan 2 36.16

Disease Link Frequency Relevance Heat Disease 1 90.00 INFLAMMATION 1 89.64 Necrosis 1 87.08 Cancer 1 86.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This study examines the role of NF-kappaB in the regulation of TNFalpha production by morphine in microglia.

NF-kappaB Spec (examines) Regulation (role) of Gene_expression (production) of TNFalpha in microglia associated with morphine

1) Confidence 0.17 Published 2009 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 19023660 Disease Relevance 0.35 Pain Relevance 0.54

General Comments

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