INT156270

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.31
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
neurons 2
Mapk8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 6 100.00 Very High Very High Very High
Neuropathic pain 8 98.40 Very High Very High Very High
Analgesic 4 96.80 Very High Very High Very High
Pain 2 95.36 Very High Very High Very High
Spinal nerve ligature 7 93.16 High High
Lasting pain 2 87.40 High High
Inflammation 14 68.88 Quite High
ischemia 1 66.52 Quite High
cva 1 65.72 Quite High
antagonist 3 61.84 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 14 100.00 Very High Very High Very High
Neuropathic Pain 9 98.40 Very High Very High Very High
Hypoxia 51 98.24 Very High Very High Very High
Injury 17 97.92 Very High Very High Very High
Pain 4 95.36 Very High Very High Very High
Apoptosis 22 87.60 High High
INFLAMMATION 14 68.88 Quite High
Reperfusion Injury 2 67.28 Quite High
Cv General 3 Under Development 1 65.72 Quite High
Inflammatory Pain 1 61.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To explore the underlying mechanisms, effects of edaravone on the excitability of dorsal root ganglion (DRG) neurons and activation of JNK in DRG were observed.
Regulation (effects) of Positive_regulation (activation) of JNK in neurons associated with ganglion cysts and dorsal root ganglion
1) Confidence 0.41 Published 2009 Journal Brain Res. Section Abstract Doc Link 19028459 Disease Relevance 1.69 Pain Relevance 1.93
In the present study, agmatine regulated the activation of JNK, but not ERK and p38, in RGC-5 cells after hypoxic injury.
Regulation (regulated) of Positive_regulation (activation) of JNK associated with hypoxia and injury
2) Confidence 0.24 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 0.56 Pain Relevance 0.11
In our investigation, MP did not affect ERK and p38 activation in rat LNC, while it had only limited, statistically non-significant effect on JNK activation.
Regulation (effect) of Positive_regulation (activation) of JNK
3) Confidence 0.12 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox