INT156280

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.55
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Sdc1) cell adhesion (Sdc1) protein complex (Sdc1)
cell-cell signaling (Sdc1) cytoplasm (Sdc1)
Anatomy Link Frequency
coronary artery 1
endothelial cells 1
pituitary 1
Sdc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 6 97.64 Very High Very High Very High
anesthesia 4 88.80 High High
fibrosis 7 42.48 Quite Low
Inflammation 38 25.00 Low Low
cytokine 25 25.00 Low Low
antagonist 39 5.00 Very Low Very Low Very Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 6 97.64 Very High Very High Very High
Adhesions 9 84.80 Quite High
Apoptosis 4 67.16 Quite High
Pulmonary Fibrosis 3 42.48 Quite Low
Wound Healing 1 40.88 Quite Low
Asthma 5 36.96 Quite Low
Cancer 41 35.96 Quite Low
Shock 1 15.92 Low Low
Pituitary Cancer 11 5.60 Low Low
Stress 48 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The shedding is accompanied by increased levels of the glycocalyx component syndecan-1 in the circulation.
Gene_expression (levels) of syndecan-1
1) Confidence 0.43 Published 2008 Journal Perfusion Section Abstract Doc Link 19029267 Disease Relevance 0.10 Pain Relevance 0.11
There were no significant differences in syndecan-1 concentrations in the two groups.
Gene_expression (concentrations) of syndecan-1
2) Confidence 0.42 Published 2008 Journal Perfusion Section Abstract Doc Link 19029267 Disease Relevance 0.06 Pain Relevance 0.12
Our aim was to compare plasma levels of syndecan-1 in patients undergoing coronary artery bypass grafting (CABG), with or without the use of cardiopulmonary bypass (CPB).
Gene_expression (levels) of syndecan-1 in coronary artery
3) Confidence 0.42 Published 2008 Journal Perfusion Section Abstract Doc Link 19029267 Disease Relevance 0.09 Pain Relevance 0.11
Moesin, a significant attachment protein, binds to the cell surface HSPG, syndecan-2 [34].
Gene_expression (syndecan) of HSPG
4) Confidence 0.23 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0.15 Pain Relevance 0
In the rat pituitary, laminin, the HSPG perlecan, and type IV collagen. are found inside nonhormonal cells whereas laminin and, to a lesser extent, type IV collagen are found in hormonal cells, suggesting that hormonal cells participate to the elaboration of BM (822).
Gene_expression (found) of HSPG in pituitary
5) Confidence 0.08 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0
The syndecans exhibit cell-type specific distribution with vascular endothelial cells (ECs) expressing syndecan-1, -2, and -4 and predominant targeting to abluminal surfaces.
Gene_expression (expressing) of syndecan-1 in endothelial cells
6) Confidence 0.08 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0.08 Pain Relevance 0
For a review on HSPG, see (13)

Morphological, Enzymatic and Energy Properties

Gene_expression (review) of HSPG
7) Confidence 0.08 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0.06 Pain Relevance 0

General Comments

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