INT156287

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.35
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
liver 1
cerebrospinal fluid 1
collecting tubules 1
body 1
G4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 24 54.28 Quite High
transdermal 22 50.00 Quite Low
diclofenac 6 50.00 Quite Low
cINOD 4 50.00 Quite Low
Bioavailability 5 33.64 Quite Low
COX2 6 10.00 Low Low
cOX1 6 10.00 Low Low
Neurotransmitter 18 9.88 Low Low
Pyramidal cell 18 5.00 Very Low Very Low Very Low
Bile 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 3 78.08 Quite High
Hepatic Encephalopathy 51 73.88 Quite High
Cirrhosis 57 65.76 Quite High
Hyperammonemia 12 62.96 Quite High
Toxicity 3 52.44 Quite High
Liver Failure 30 50.76 Quite High
INFLAMMATION 4 50.00 Quite Low
Colon Cancer 1 42.72 Quite Low
Targeted Disruption 3 22.60 Low Low
Liver Disease 24 15.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Creatinine clearance decreased in G4 compared with the other groups.
Negative_regulation (decreased) of G4
1) Confidence 0.41 Published 2009 Journal Int Urol Nephrol Section Body Doc Link 19031110 Disease Relevance 0.06 Pain Relevance 0
RESULTS: Compared with G1, body weights were significantly reduced in G3 and G4 (P < 0.05 for all).
Negative_regulation (reduced) of G4 in body
2) Confidence 0.41 Published 2009 Journal Int Urol Nephrol Section Body Doc Link 19031110 Disease Relevance 0.08 Pain Relevance 0
Moreover, we have recently showed in BDL rats a pronounced decrease in liver and plasma AChE levels, with selective loss of the G4 specie (García-Ayllón et al., 2006).
Negative_regulation (loss) of G4 in liver
3) Confidence 0.32 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.42 Pain Relevance 0.03
COX-1 expression in cortical collecting tubules was significantly reduced in G3 and G4 compared with G1 and G2 (P < 0.05 for all).
Negative_regulation (reduced) of G4 in collecting tubules
4) Confidence 0.30 Published 2009 Journal Int Urol Nephrol Section Body Doc Link 19031110 Disease Relevance 0 Pain Relevance 0
The decrease of serum G4 levels in BDL rats correlates with a decrease of the tetrameric species in the cerebrospinal fluid (unpublished observation).
Negative_regulation (decrease) of G4 in cerebrospinal fluid
5) Confidence 0.23 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.32 Pain Relevance 0.03
Their intention was to study absorption of these dendrimer from Sprague-Dawley rats following oral administration for which they preferred G4 dendrimer with a diameter of 2.5 nm having molecular weight of 6300 and log P (octanol/water) of 1.24.
Negative_regulation (preferred) of G4
6) Confidence 0.23 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792561 Disease Relevance 0.05 Pain Relevance 0
Moreover, we have recently showed in BDL rats a pronounced decrease in liver and plasma AChE levels, with selective loss of the G4 specie (García-Ayllón et al., 2006).
Negative_regulation (loss) of G4 in plasma
7) Confidence 0.11 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.42 Pain Relevance 0.03

General Comments

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