INT156296

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 7.84
Pain Relevance 4.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv4) plasma membrane (Trpv4) cilium (Trpv4)
transmembrane transport (Trpv4)
Anatomy Link Frequency
bladder 1
MDCK 1
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 79 100.00 Very High Very High Very High
Neuropathic pain 34 100.00 Very High Very High Very High
agonist 142 99.56 Very High Very High Very High
Analgesic 17 99.20 Very High Very High Very High
Pain 302 98.56 Very High Very High Very High
nud 2 98.52 Very High Very High Very High
antagonist 128 97.36 Very High Very High Very High
nociceptor 157 96.60 Very High Very High Very High
ischemia 4 95.00 High High
Mechanotransduction 10 94.96 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 76 100.00 Very High Very High Very High
INFLAMMATION 76 100.00 Very High Very High Very High
Stress 93 99.44 Very High Very High Very High
Nociception 70 99.40 Very High Very High Very High
Pain 311 98.56 Very High Very High Very High
Dyspepsia 2 98.52 Very High Very High Very High
Pressure And Volume Under Development 40 97.28 Very High Very High Very High
Cardiovascular Disease 1 97.16 Very High Very High Very High
Disease 66 96.36 Very High Very High Very High
Hypertension 7 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the most recent annual meeting of the International Continence Society (San Francisco, CA, USA, 29 September to 3 October 2009), several posters about the role of TRPV4 channels in bladder physiology and their possible involvement in bladder overactivity were presented.
Spec (possible) Regulation (role) of TRPV4 in bladder
1) Confidence 0.45 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.14 Pain Relevance 0.22
The effects of TRPV4 and TRPA1 agonists on [Ca(2+)](i), pain and inflammation were markedly diminished or abolished in trpv4 and trpa1 knockout mice.
Regulation (effects) of TRPV4 associated with targeted disruption, pain, inflammation and agonist
2) Confidence 0.45 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20539005 Disease Relevance 1.52 Pain Relevance 1.40
These observations reveal for the first time that activation of AT1aR can trigger internalization and functional down-regulation of TRPV4, and the data uncover an entirely novel functional attribute for the heterodimerization between AT1aR and TRPV4.
Regulation (regulation) of TRPV4
3) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0.07
-arrestin interaction with TRPV4 and describe a novel regulatory mechanism governing the functional down-regulation of TRPV4.
Regulation (regulation) of TRPV4
4) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0.40 Pain Relevance 0.08
-arrestin 2 using siRNA and studied its effect on TRPV4 ubiquitination.
Regulation (effect) of TRPV4
5) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
-arrestin 1 and TRPV4 and provide a novel mechanism for regulation of TRPV4 (a schematic representation is shown in Fig. 6).
Regulation (regulation) of TRPV4
6) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0.11
-arrestin 1, and subsequently to internalization and functional down-regulation of TRPV4. ?
Regulation (regulation) of TRPV4
7) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
This represents an entirely novel mechanism to exert precise control over TRPV4-mediated Ca2+ influx in cells to avoid the unwanted consequences of excessive Ca2+ signaling.
Regulation (control) of TRPV4-mediated
8) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0.03
Taken together with the data presented in Fig. 1, A–D, these findings establish the formation of a previously unsuspected multiprotein complex involving TRPV4, AT1aR, and ?
Regulation (involving) of TRPV4
9) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
These studies suggest that TRPV4 is involved in both inflammatory and neuropathic pain and play a key role in mechanical nociception.
Regulation (role) of TRPV4 associated with nociception, inflammation and neuropathic pain
10) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 1.47 Pain Relevance 0.75
On a final note, this novel role of TRPV4 not only advances our basic understanding of vascular physiology, it also renders TRPV4 an appealing target [50], [51] for therapeutic manipulation of arterial diameter, e.g. in cardiovascular disease states like hypertension [52], ischemia-reperfusion-induced vascular injury, and, last but not least, in atherosclerosis, where chronic mechanical shear stress and inappropriate endothelial Ca2+ influx have been suggested to be pathogenic for regional lesion development and progression (e.g. at the carotid bifurcation).
Regulation (target) of TRPV4 associated with stress, cardiovascular disease, ischemia, hypertension, increased venous pressure under development and vasculitis
11) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1959246 Disease Relevance 1.35 Pain Relevance 0.18
Furthermore, robust flow-induced Ca2+ signals were observed in MDCK cells expressing a TRPV4 siRNA with a two-base mismatch, which does not alter TRPV4 expression levels (Fig.
Neg (not) Regulation (alter) of TRPV4 in MDCK
12) Confidence 0.27 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.20 Pain Relevance 0
To address the question of whether the TRPP2 effect on swelling-activated currents is simply mediated through increased surface expression of TRPV4, we inserted a V5 tag into the first extracellular loop of TRPV4 and TRPP2, respectively, and monitored either ion channel at the cell surface using a modified ELISA system (Wegierski et al., 2006).
Regulation (loop) of TRPV4 associated with pressure and volume under development
13) Confidence 0.27 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.35 Pain Relevance 0
So what role does angiotensin-induced ubiquitination of TRPV4 play in its regulation?
Regulation (regulation) of TRPV4
14) Confidence 0.25 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
Therefore, targeting TRPV4 at the central terminals may be a useful strategy to combat certain modalities of pain.
Regulation (targeting) of TRPV4 associated with pain
15) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 0.54 Pain Relevance 0.76
As is the case for other TRPs, mechanical and chemical sensitivity of TRPV4 is strongly modulated by temperature [71].
Regulation (modulated) of TRPV4
16) Confidence 0.22 Published 2008 Journal Mol Pain Section Body Doc Link PMC2386863 Disease Relevance 0.30 Pain Relevance 0.15
Given the wide distribution, function and complexity in modulation of TRPV4, it would be a challenge to target the receptor with agonists or antagonists for specific disease states.


Regulation (modulation) of TRPV4 associated with antagonist, agonist and disease
17) Confidence 0.17 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 1.38 Pain Relevance 1.02
The presence of intracellular components that interact and regulate TRPV4 channel expression and function were evident from the fact that it cannot be activated by heat in a membrane de-limited condition [228], necessitating the presence of intracellular components as modulators.
Regulation (regulate) of TRPV4
18) Confidence 0.17 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0 Pain Relevance 0.10
Lyn, a member of Src-family of tyrosine kinases, mediated tyrosine phosphorylation at Tyr-253 residue to regulate TRPV4 response to hypotonic stress [224, 236].
Regulation (response) of TRPV4 associated with stress
19) Confidence 0.17 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.18 Pain Relevance 0
Src family tyrosine kinases (SFKs) regulate the function of several transient receptor potential (TRP) family members, yet their role in the regulation of the vanilloid subfamily member 4 protein (TRPV4) remains controversial.
Regulation (regulation) of vanilloid subfamily member 4 protein
20) Confidence 0.01 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19033444 Disease Relevance 0 Pain Relevance 0

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