INT156299

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Context Info
Confidence 0.80
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 2.46
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)
Trpv4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 16 99.60 Very High Very High Very High
IPN 8 99.52 Very High Very High Very High
Inflammation 10 95.60 Very High Very High Very High
Hyperalgesia 23 95.08 Very High Very High Very High
Pain 41 87.52 High High
Neuropathic pain 12 71.44 Quite High
Taxol 90 66.48 Quite High
vincristine 6 65.68 Quite High
dorsal root ganglion 48 5.00 Very Low Very Low Very Low
imagery 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 8 99.52 Very High Very High Very High
INFLAMMATION 10 95.60 Very High Very High Very High
Hyperalgesia 23 95.08 Very High Very High Very High
Pain 36 87.52 High High
Nociception 42 86.56 High High
Pressure And Volume Under Development 5 81.04 Quite High
Stress 10 80.04 Quite High
Cancer 9 75.20 Quite High
Neuropathic Pain 15 71.44 Quite High
Congenital Anomalies 3 56.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This kinase activity is important for TRPV4 function [66] as it phosphorylates TRPV4 [43], [93].
Phosphorylation (phosphorylates) of TRPV4
1) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.66 Pain Relevance 0.45
most likely sequesters at the C-terminus of the TRPV4 in order to phosphorylate the N-terminus and/or it needs other factors.
Phosphorylation (phosphorylate) of TRPV4
2) Confidence 0.79 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.15 Pain Relevance 0.08
Using mass spectrometry, we report now that TRPV4 is phosphorylated on serine 824 by the PKC-activating phorbol 12-myristate 13-acetate.
Phosphorylation (phosphorylated) of TRPV4 associated with kinase c
3) Confidence 0.66 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20043876 Disease Relevance 0.34 Pain Relevance 0.64
Thus PKC, and possibly PKA, phosphorylate TRPV4 at Ser824 leading to the enhancement of TRPV4 channel function.
Phosphorylation (phosphorylate) of TRPV4 associated with kinase c
4) Confidence 0.66 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20043876 Disease Relevance 0.24 Pain Relevance 0.61
Substitution of either tyrosine with phenylalanine led to a substantial reduction in the overall tyrosine phosphorylation level of TRPV4, suggesting that these two tyrosines constitute major phosphorylation sites.
Phosphorylation (phosphorylation) of TRPV4
5) Confidence 0.62 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19033444 Disease Relevance 0.14 Pain Relevance 0
Reactive oxygen species, known to mediate inflammatory pain, strongly up-regulated TRPV4 phosphorylation in the presence of SFKs.
Phosphorylation (phosphorylation) of TRPV4 associated with ipn
6) Confidence 0.62 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19033444 Disease Relevance 0.26 Pain Relevance 0.22
Our findings indicate that tyrosine phosphorylation of TRPV4 represents an important modulatory mechanism, which may underlie the recently described function of TRPV4 in inflammatory hyperalgesia.
Phosphorylation (phosphorylation) of TRPV4 associated with hyperalgesia and inflammation
7) Confidence 0.62 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19033444 Disease Relevance 0.44 Pain Relevance 0.24
Here we show that SFKs mediate tyrosine phosphorylation of TRPV4 in different cell lines.
Phosphorylation (phosphorylation) of TRPV4
8) Confidence 0.62 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19033444 Disease Relevance 0 Pain Relevance 0
Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli.
Phosphorylation (phosphorylation) of TRPV4
9) Confidence 0.62 Published 2009 Journal J. Biol. Chem. Section Title Doc Link 19033444 Disease Relevance 0.11 Pain Relevance 0
However, a recent study has demonstrated that in vivo condition, S824 position of the TRPV4 is phosphorylated by PKC [91].
Phosphorylation (phosphorylated) of TRPV4
10) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.11 Pain Relevance 0.06

General Comments

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