INT156301

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Context Info
Confidence 0.60
First Reported 2009
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 19
Disease Relevance 2.81
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)
Anatomy Link Frequency
spinal 1
DRG 1
F11 1
Trpv4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Taxol 270 99.84 Very High Very High Very High
Kinase C 8 99.44 Very High Very High Very High
imagery 109 99.16 Very High Very High Very High
dorsal root ganglion 152 89.52 High High
Hyperalgesia 43 82.16 Quite High
qutenza 2 81.56 Quite High
agonist 54 75.92 Quite High
member 8 1 71.60 Quite High
addiction 1 67.28 Quite High
Calcium channel 3 66.80 Quite High
Disease Link Frequency Relevance Heat
Asthma 7 99.84 Very High Very High Very High
Spinal Muscular Atrophy 2 99.28 Very High Very High Very High
Pulmonary Disease 1 98.72 Very High Very High Very High
Pain 112 97.64 Very High Very High Very High
Neuropathic Pain 46 96.68 Very High Very High Very High
Ganglion Cysts 152 96.08 Very High Very High Very High
Charcot Marie Tooth Disease 2 94.48 High High
Hypersensitivity 1 94.28 High High
Mouth Disease 1 93.92 High High
Shock 18 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In turn, we describe that microtubule dynamics are an important regulator of TRPV4 activity.
Regulation (regulator) of TRPV4
1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2906515 Disease Relevance 0.06 Pain Relevance 0.07
In turn, we describe that microtubule dynamics are an important regulator of TRPV4 activity.
Regulation (regulator) of TRPV4
2) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link 20657843 Disease Relevance 0 Pain Relevance 0
Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study.
Regulation (Modulation) of TRPV4
3) Confidence 0.53 Published 2009 Journal J. Med. Chem. Section Title Doc Link 19361196 Disease Relevance 0 Pain Relevance 0.16
In contrast to a unidirectional effect of TRPV4 activation on microtubule integrity, we explored if microtubule dynamics can also affect the TRPV4 channel properties.
Regulation (affect) of TRPV4
4) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.16
Substitution of Ser824 with aspartic acid, mimicking phosphorylation at this site, increased TRPV4-mediated calcium influx in resting and in stimulated cells, underlining the importance of this residue in TRPV4 regulation.
Regulation (regulation) of TRPV4
5) Confidence 0.50 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20043876 Disease Relevance 0.25 Pain Relevance 0.62
Real-time reverse transcription polymerase chain reaction and Western blot analysis were performed to assess the change of TRPV4 messenger RNA (mRNA) and protein expression in DRG.
Regulation (change) of TRPV4 in DRG
6) Confidence 0.45 Published 2010 Journal Neurol. Res. Section Body Doc Link 19278577 Disease Relevance 0.17 Pain Relevance 0
For visualizing the effect of TRPV4 activation, F11 cells were seeded on glass cover slips.
Regulation (effect) of TRPV4 in F11
7) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.15
This result suggests a stabilization effect of MBP-TRPV4-Ct on microtubules.


Regulation (effect) of TRPV4
8) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.03
CONCLUSIONS AND SIGNIFICANCE: TRPV4 acts as a regulator for both, the microtubule and the actin.
Regulation (regulator) of TRPV4
9) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link 20657843 Disease Relevance 0 Pain Relevance 0
Src family tyrosine kinases (SFKs) regulate the function of several transient receptor potential (TRP) family members, yet their role in the regulation of the vanilloid subfamily member 4 protein (TRPV4) remains controversial.
Regulation (regulation) of TRPV4
10) Confidence 0.27 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19033444 Disease Relevance 0 Pain Relevance 0
Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli.
Regulation (modulates) of TRPV4
11) Confidence 0.27 Published 2009 Journal J. Biol. Chem. Section Title Doc Link 19033444 Disease Relevance 0.11 Pain Relevance 0
On one hand TRPV4 regulates stability-instability of the microtubules and reorganizes them, on the other hand microtubule dynamics regulate the Ca2+-influx through TRPV4.
Regulation (regulate) of TRPV4
12) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.08 Pain Relevance 0.17
S7), we confirmed that the presence of microtubules and TRPV4 at the cell membrane or nearby regions was also not altered by Taxol application.
Neg (not) Regulation (altered) of TRPV4 associated with taxol
13) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.07 Pain Relevance 0.31
Along the same line, evidence suggests that the actin cytoskeleton can also regulate the TRPV4 channel activity as disruption of the actin cytoskeleton impairs the TRPV4-mediated currents [70] and Ca2+-influx in TRPV4 expressing cells in response to hypotonic shock [68].
Regulation (regulate) of TRPV4 associated with shock
14) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.15 Pain Relevance 0.23
Regulation of TRPV4 activity by actin and microtubule cytoskeleton
Regulation (Regulation) of TRPV4
15) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.09 Pain Relevance 0.11
However, to date, there is no information about the genetic impact of either TRPV1 or TRPV4 on asthma pathophysiology.
Neg (no) Regulation (information) of TRPV4 associated with asthma
16) Confidence 0.25 Published 2010 Journal J. Biol. Chem. Section Abstract Doc Link 20639579 Disease Relevance 0.90 Pain Relevance 0
METHODS: Two pairs of siRNA targeting TRPV4 (siRNAa and siRNAb) were designed and synthesized.
Regulation (targeting) of TRPV4
17) Confidence 0.23 Published 2010 Journal Neurol. Res. Section Body Doc Link 19278577 Disease Relevance 0.19 Pain Relevance 0
Taken together, these results suggest that microtubule dynamics can regulate TRPV4 channel properties.


Regulation (regulate) of TRPV4
18) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.08 Pain Relevance 0.25
Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4.
Regulation (alterations) of TRPV4 in spinal associated with spinal muscular atrophy
19) Confidence 0.09 Published 2010 Journal Nat. Genet. Section Title Doc Link 20037587 Disease Relevance 0.66 Pain Relevance 0.10

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