INT156302

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Context Info
Confidence 0.46
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.92
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)
Trpv4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 2 99.78 Very High Very High Very High
Pain 13 87.52 High High
Inflammation 2 84.32 Quite High
Hyperalgesia 5 83.28 Quite High
Neuropathic pain 4 71.44 Quite High
Taxol 30 66.48 Quite High
vincristine 2 65.68 Quite High
dorsal root ganglion 16 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 99.78 Very High Very High Very High
Pain 12 87.52 High High
Nociception 14 86.56 High High
Pressure And Volume Under Development 1 81.56 Quite High
Stress 2 80.56 Quite High
Cancer 3 75.20 Quite High
Neuropathic Pain 5 71.44 Quite High
Congenital Anomalies 1 56.96 Quite High
Hyperalgesia 5 9.92 Low Low
Ganglion Cysts 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reactive oxygen species, known to mediate inflammatory pain, strongly up-regulated TRPV4 phosphorylation in the presence of SFKs.
Positive_regulation (up-regulated) of Phosphorylation (phosphorylation) of TRPV4 associated with ipn
1) Confidence 0.46 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19033444 Disease Relevance 0.26 Pain Relevance 0.23
This kinase activity is important for TRPV4 function [66] as it phosphorylates TRPV4 [43], [93].
Positive_regulation (phosphorylates) of Phosphorylation (phosphorylates) of TRPV4
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.66 Pain Relevance 0.45

General Comments

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