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Context Info
Confidence 0.27
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.26
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)
Trpv4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 8 99.44 Very High Very High Very High
Hyperalgesia 4 82.16 Quite High
Inflammation 2 64.44 Quite High
Pain 1 60.56 Quite High
IPN 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hyperalgesia 4 72.08 Quite High
INFLAMMATION 2 64.44 Quite High
Stress 2 57.16 Quite High
Pressure And Volume Under Development 1 29.60 Quite Low
Inflammatory Pain 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Src family tyrosine kinases (SFKs) regulate the function of several transient receptor potential (TRP) family members, yet their role in the regulation of the vanilloid subfamily member 4 protein (TRPV4) remains controversial.
Regulation (role) of Regulation (regulation) of TRPV4
1) Confidence 0.27 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19033444 Disease Relevance 0 Pain Relevance 0
Substitution of Ser824 with aspartic acid, mimicking phosphorylation at this site, increased TRPV4-mediated calcium influx in resting and in stimulated cells, underlining the importance of this residue in TRPV4 regulation.
Regulation (importance) of Regulation (regulation) of TRPV4
2) Confidence 0.22 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20043876 Disease Relevance 0.26 Pain Relevance 0.63

General Comments

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