INT156348

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 6.79
Pain Relevance 4.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hypothalamus 1
spinal 1
nerve 1
muscle fibers 1
Mup1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 100.00 Very High Very High Very High
Demyelination 21 99.64 Very High Very High Very High
Pain 150 99.16 Very High Very High Very High
carpal tunnel syndrome 757 98.78 Very High Very High Very High
Action potential 105 67.12 Quite High
Inflammation 8 41.36 Quite Low
Sciatica 21 30.24 Quite Low
alcohol 8 5.00 Very Low Very Low Very Low
peripheral neuropathy 7 5.00 Very Low Very Low Very Low
rheumatoid arthritis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overactive Bladder 9 100.00 Very High Very High Very High
Demyelinating Disease 21 99.64 Very High Very High Very High
Neuropathic Pain 106 99.58 Very High Very High Very High
Pain 147 99.16 Very High Very High Very High
Injury 43 99.00 Very High Very High Very High
Carpal Tunnel Syndrome 771 98.78 Very High Very High Very High
Metabolic Syndrome 8 84.44 Quite High
Disease 15 81.00 Quite High
Fatigue 12 77.44 Quite High
Apoptosis 3 72.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In previous transcriptomic studies conducted with the SAGE method, Mup1 gene was also significantly regulated by feeding in the duodenum mucosa and hypothalamus of mice [13, 14].
Regulation (regulated) of Mup1 gene in hypothalamus
1) Confidence 0.52 Published 2010 Journal Journal of Obesity Section Body Doc Link PMC3017904 Disease Relevance 0.22 Pain Relevance 0
In conclusion, we present a set of parameters derived from the interpeak latency method, which yields information about changes in MUP velocities’ distribution and amount of MUP activity.
Regulation (changes) of MUP
2) Confidence 0.43 Published 2007 Journal Eur J Appl Physiol Section Body Doc Link PMC2039775 Disease Relevance 0.24 Pain Relevance 0.09
Both MUP and SMUP duration is thought to be influenced by axonal injury, and have been examined previously [10], however MUP durations are also heavily dependent on the distance of the active motor unit to the recording electrode [5].
Spec (examined) Regulation (dependent) of MUP associated with injury
3) Confidence 0.38 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 0.64 Pain Relevance 0.48
The DQEMG results indicated that, although the MUP amplitudes tended to be larger for the higher contraction levels, based on one-way ANOVA results, there was no significant difference in the MUP amplitudes between the two contraction levels (F = 2.45; p = 0.156; See Table 5), which were both substantially lower than the amplitudes seen in the severe CTS group in our study.
Regulation (larger) of MUP associated with carpal tunnel syndrome
4) Confidence 0.38 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 0.48 Pain Relevance 0.40
For each MUPT a MUP template was calculated using median-trimmed averaging of the 51 most similar MUP samples from the train.
Regulation (calculated) of MUP
5) Confidence 0.38 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 0 Pain Relevance 0
A retrospective, descriptive, exploratory study evaluating incidence of postoperative urinary retention after spinal anesthesia and its effect on PACU discharge.
Regulation (effect) of urinary retention in spinal associated with anesthesia and overactive bladder
6) Confidence 0.23 Published 2008 Journal J. Perianesth. Nurs. Section Title Doc Link 19038746 Disease Relevance 0.79 Pain Relevance 0.10
Despite the different levels of %MVC across the study groups elicited by the constant-intensity protocol the MUPs with significantly larger amplitudes and longer durations in individuals with severe CTS suggest motor unit loss and that orphaned muscle fibers in the participants with severe CTS had undergone collateral reinnervation, however significant changes in MUP stability were not detected using DQEMG.
Regulation (changes) of MUP in muscle fibers associated with carpal tunnel syndrome
7) Confidence 0.23 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 0.84 Pain Relevance 0.70
Based on the current findings it appears that quantitative EMG may be a sensitive measure to detect MUP morphological changes in individuals with compressive neuropathy but not necessarily changes in MUP complexity or stability.
Regulation (changes) of MUP associated with neuropathic pain
8) Confidence 0.23 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 0.89 Pain Relevance 0.68
The lower MUNEs found in the mild CTS group as compared to the healthy control group suggest that traditional nerve conduction studies may not be as sensitive to subtle motor impairments that may result from early demyelination as are MUNEs and MUP morphological feature values obtained using DQEMG.


Regulation (values) of MUP in nerve associated with demyelination and carpal tunnel syndrome
9) Confidence 0.23 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 0.91 Pain Relevance 0.74
Based on the current findings it appears that quantitative EMG may be a sensitive measure to detect MUP morphological changes in individuals with compressive neuropathy but not necessarily changes in MUP complexity or stability.
Neg (not) Regulation (changes) of MUP associated with neuropathic pain
10) Confidence 0.23 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 0.94 Pain Relevance 0.73
MUP duration and AAR values were significantly larger in the NSAP, LE and at-risk groups compared to the control group (p < 0.006); while MUP amplitude, duration and AAR values were smaller in the NSAP compared to the LE group.
Regulation (values) of MUP associated with pain
11) Confidence 0.14 Published 2008 Journal J Neuroeng Rehabil Section Abstract Doc Link PMC2654455 Disease Relevance 0.84 Pain Relevance 0.67

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