INT156365

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.63
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hhex) DNA binding (Hhex) cytoplasm (Hhex)
cell proliferation (Hhex) signal transduction (Hhex) nucleus (Hhex)
Anatomy Link Frequency
ear 1
kidney 1
Hhex (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 1 56.32 Quite High
Analgesic 7 50.00 Quite Low
Inflammation 6 50.00 Quite Low
Antinociceptive 2 50.00 Quite Low
Acute pain 2 50.00 Quite Low
Pain 2 10.00 Low Low
qutenza 1 10.00 Low Low
imagery 27 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cyst 25 99.80 Very High Very High Very High
Diabetes Mellitus 91 99.76 Very High Very High Very High
Albuminuria 4 99.40 Very High Very High Very High
Autosomal Dominant Polycystic Kidney 111 90.04 High High
Pain 2 51.64 Quite High
Syndrome 15 50.00 Quite Low
INFLAMMATION 4 50.00 Quite Low
Wound Healing 1 50.00 Quite Low
Chronic Renal Failure 26 44.40 Quite Low
Injury 2 6.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EtOH, HEX and AcOEt (62.5-250 mg/kg) produced a significant antinociceptive effect in the formalin and capsaicin tests.
Gene_expression (produced) of HEX
1) Confidence 0.67 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 20304040 Disease Relevance 0.05 Pain Relevance 0
MATERIALS AND METHODS: Hexane, (Hex), ethyl acetate (EtOAc), methanol (MeOH) and 50% methanol (MeOH50) fractions of the dry leaves were tested in vitro for their interleukin-10 production; the most active fraction was further studied in vivo for its anti-inflammatory and analgesic activities using the ethylphenylpropiolate (EPP)-induced mouse ear edema and the writhing test with mice.
Gene_expression (production) of Hex in ear
2) Confidence 0.66 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19041700 Disease Relevance 0 Pain Relevance 0
In this study, we found a significant association between all three SNPs typed, including rs1111875, rs7923837 and rs5015480, in the IDE-KIF11-HHEX region, and T2D in the Chinese population.
Gene_expression (region) of IDE-KIF11-HHEX associated with diabetes mellitus
3) Confidence 0.19 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2894791 Disease Relevance 0.83 Pain Relevance 0
Furthermore, keeping age constant, they reported a partial significant correlation between the ultrasound score (kidney size and number of cysts) and the proportion of Hex B, but not with albuminuria or cystatin C.
Gene_expression (proportion) of Hex B in kidney associated with cyst and albuminuria
4) Confidence 0.13 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 0.75 Pain Relevance 0.03

General Comments

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