INT156377

Context Info Confidence 0.43 First Reported 2009 Last Reported 2009 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.17 Pain Relevance 0.51

plasma membrane (Dlg4) protein complex assembly (Dlg4) response to stress (Dlg4) cytoplasm (Dlg4)

Dlg4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 9 99.80 nMDA receptor 1 75.00 Neurobehavioral 1 25.00 Opioid 1 25.00

Disease Link Frequency Relevance Heat Cognitive Disorder 3 90.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this study, we determined whether prenatal morphine exposure altered the synaptic complex association between PSD-95 and three major NMDAR subunits (NR1, NR2A, and NR2B), at the mRNA and protein levels, within the hippocampal CA1 subregion (an important integration area for mammalian learning and memory) of rat offspring along with the performance of long-term cognitive functions.

Spec (whether) Regulation (altered) of PSD-95 Binding (association) of associated with cognitive disorder and morphine

1) Confidence 0.43 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.17 Pain Relevance 0.51

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