INT156380

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.32
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1, Dlg4) cytoplasm (Grin1, Dlg4) protein complex assembly (Dlg4)
enzyme binding (Grin1) response to stress (Dlg4)
Grin1 (Rattus norvegicus)
Dlg4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 2 100.00 Very High Very High Very High
Morphine 18 99.98 Very High Very High Very High
Neurobehavioral 2 25.00 Low Low
Opioid 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 6 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we determined whether prenatal morphine exposure altered the synaptic complex association between PSD-95 and three major NMDAR subunits (NR1, NR2A, and NR2B), at the mRNA and protein levels, within the hippocampal CA1 subregion (an important integration area for mammalian learning and memory) of rat offspring along with the performance of long-term cognitive functions.
Spec (whether) Regulation (altered) of NR1 Binding (association) of PSD-95 associated with cognitive disorder and morphine
1) Confidence 0.29 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.17 Pain Relevance 0.52
Prenatal morphine alters the synaptic complex of postsynaptic density 95 with N-methyl-D-aspartate receptor subunit in hippocampal CA1 subregion of rat offspring leading to long-term cognitive deficits.
Regulation (alters) of N-methyl-D-aspartate receptor Binding (complex) of postsynaptic density 95 associated with cognitive disorder, nmda receptor and morphine
2) Confidence 0.22 Published 2009 Journal Neuroscience Section Title Doc Link 19041927 Disease Relevance 0.16 Pain Relevance 0.45

General Comments

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