INT156383

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.61
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc17a5) cytoplasmic membrane-bounded vesicle (Slc17a5) plasma membrane (Slc17a5)
transmembrane transport (Slc17a5) lysosome (Slc17a5)
Anatomy Link Frequency
plasma 4
Slc17a5 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 110 99.82 Very High Very High Very High
Pain management 3 90.08 High High
Inflammation 22 81.16 Quite High
Analgesic 2 44.80 Quite Low
alcohol 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 9 92.64 High High
Pain 5 90.08 High High
Nephrotoxicity 1 88.44 High High
Hepatotoxicity 9 86.08 High High
INFLAMMATION 22 81.16 Quite High
Drug Induced Neurotoxicity 4 61.52 Quite High
Toxicity 43 53.24 Quite High
Necrosis 15 48.84 Quite Low
Cardiovascular Disorder Under Development 9 33.04 Quite Low
Gastrointestinal Stromal Tumor 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, APAP induced increases in plasma AST and ALT levels in the highest dose group only, and the DNA damage in the liver increased at the same dose.
Positive_regulation (increased) of Positive_regulation (increases) of AST in plasma associated with paracetamol
1) Confidence 0.31 Published 2008 Journal J Toxicol Sci Section Abstract Doc Link 19043273 Disease Relevance 0.09 Pain Relevance 0.39
Clinical trials in mRCC patients had shown that liver and renal functions are affected by sunitinib leading to elevated AST, ALT and creatinine plasma levels [11].
Positive_regulation (leading) of Positive_regulation (elevated) of AST in plasma
2) Confidence 0.26 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.52 Pain Relevance 0.84

General Comments

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