INT156383

Context Info Confidence 0.31 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.61 Pain Relevance 1.23

transport (Slc17a5) cytoplasmic membrane-bounded vesicle (Slc17a5) plasma membrane (Slc17a5) transmembrane transport (Slc17a5) lysosome (Slc17a5)

Anatomy Link Frequency plasma 4 Slc17a5 (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 110 99.82 Pain management 3 90.08 Inflammation 22 81.16 Analgesic 2 44.80 alcohol 4 5.00 Pain 2 5.00 fibrosis 1 5.00 cva 1 5.00

Disease Link Frequency Relevance Heat Cancer 9 92.64 Pain 5 90.08 Nephrotoxicity 1 88.44 Hepatotoxicity 9 86.08 INFLAMMATION 22 81.16 Drug Induced Neurotoxicity 4 61.52 Toxicity 43 53.24 Necrosis 15 48.84 Cardiovascular Disorder Under Development 9 33.04 Gastrointestinal Stromal Tumor 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

On the other hand, APAP induced increases in plasma AST and ALT levels in the highest dose group only, and the DNA damage in the liver increased at the same dose.

Positive_regulation (increased) of Positive_regulation (increases) of AST in plasma associated with paracetamol

1) Confidence 0.31 Published 2008 Journal J Toxicol Sci Section Abstract Doc Link 19043273 Disease Relevance 0.09 Pain Relevance 0.39

Clinical trials in mRCC patients had shown that liver and renal functions are affected by sunitinib leading to elevated AST, ALT and creatinine plasma levels [11].

Positive_regulation (leading) of Positive_regulation (elevated) of AST in plasma

2) Confidence 0.26 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.52 Pain Relevance 0.84

General Comments

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