INT1564

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Context Info
Confidence 0.80
First Reported 1978
Last Reported 2010
Negated 2
Speculated 4
Reported most in Abstract
Documents 41
Total Number 48
Disease Relevance 8.03
Pain Relevance 44.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
plasma 4
spinal cord 3
dorsal horn 3
macrophages 2
endothelial cells 2
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 1098 100.00 Very High Very High Very High
mu opioid receptor 288 100.00 Very High Very High Very High
Enkephalin 71 100.00 Very High Very High Very High
Endogenous opioid 52 100.00 Very High Very High Very High
opiate 48 100.00 Very High Very High Very High
substance P 18 100.00 Very High Very High Very High
gABA 8 100.00 Very High Very High Very High
noradrenaline 7 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
Opioid receptor 1 1 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nicotine Addiction 196 99.20 Very High Very High Very High
Urological Neuroanatomy 97 98.72 Very High Very High Very High
Stress 13 98.64 Very High Very High Very High
Pain 237 98.20 Very High Very High Very High
Nociception 56 96.76 Very High Very High Very High
Pheochromocytoma 39 96.12 Very High Very High Very High
Lung Cancer 4 95.20 Very High Very High Very High
Fatigue 2 93.52 High High
Targeted Disruption 17 91.96 High High
Drug Dependence 33 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was supposed that the inhibition of intestinal peristalsis seen in animals and humans after abdominal surgery might be related to the release of endorphins, endogenous opiate receptor agonists, caused by the surgical stress and pain.
Localization (release) of opiate receptor associated with stress, pain, agonist and opiate
1) Confidence 0.80 Published 1978 Journal Experientia Section Abstract Doc Link 216571 Disease Relevance 0.20 Pain Relevance 0.47
Co-transfection of MOR-GFP and SV-DsRed gene showed that MOR and SV protein co-localized at the cytoplasmic membrane.
Localization (localized) of MOR associated with opioid receptor
2) Confidence 0.78 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16580639 Disease Relevance 0.08 Pain Relevance 0.81
We also observed colocalization of EM-2-LI and MOR-1-LI in a few fibers of lamina II, and colocalization of EM-2-LI and MOR-1C-LI in laminae I-II, and V-VI.
Localization (colocalization) of MOR in EM-2
3) Confidence 0.78 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12383236 Disease Relevance 0 Pain Relevance 0.64
The observed intracellular localization of the MOR1K receptor isoform, while relatively rare, is well described for other functional receptor systems.
Localization (localization) of MOR1K
4) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0 Pain Relevance 0.31
DAMGO induced arrestin-2 translocation to the plasma membrane and considerable MOR1 internalization, whereas morphine did not induce arrestin-2 translocation and induced very little MOR1 internalization.
Localization (translocation) of MOR1 in plasma associated with morphine
5) Confidence 0.75 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16682505 Disease Relevance 0 Pain Relevance 1.64
Similarly, exposure of the sst(2A)-MOR1 heterodimer to the mu-selective ligand [d-Ala(2),Me-Phe(4),Gly(5)-ol]enkephalin induced phosphorylation and desensitization of both MOR1 and sst(2A) but not internalization of sst(2A).
Localization (internalization) of MOR1 associated with enkephalin
6) Confidence 0.75 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11896051 Disease Relevance 0 Pain Relevance 0.27
Immunohistochemical localization of the carboxy terminus of the novel mu opioid receptor splice variant MOR-1C within the human spinal cord.
Localization (localization) of MOR-1C in spinal cord associated with mu opioid receptor and spinal cord
7) Confidence 0.75 Published 2000 Journal Neuroreport Section Title Doc Link 10884050 Disease Relevance 0 Pain Relevance 0.42
Chronic ethanol induces changes in opiate receptor function and in met-enkephalin release.
Localization (release) of opiate receptor associated with enkephalin, opiate and immobilon
8) Confidence 0.72 Published 1985 Journal Alcohol Section Title Doc Link 2990502 Disease Relevance 0 Pain Relevance 0.97
Immunohistochemical localization of the carboxy terminus of the novel mu opioid receptor splice variant MOR-1C within the human spinal cord.
Localization (localization) of mu opioid receptor in spinal cord associated with mu opioid receptor and spinal cord
9) Confidence 0.70 Published 2000 Journal Neuroreport Section Title Doc Link 10884050 Disease Relevance 0 Pain Relevance 0.42
Antisense to all three opioid receptors attenuated the effect of diazoxide, suggesting that diazoxide is inducing the release of endogenous opioids activating the mu(MOR-1)-, delta(DOR-1)-, and kappa(KOR-1)-opioid receptors.
Localization (release) of MOR-1 associated with endogenous opioid and opioid receptor
10) Confidence 0.68 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10611434 Disease Relevance 0 Pain Relevance 1.20
Interestingly, the OPRM1 gene is located at 6q24-25, about 4 million basepairs from a suggestive linkage peak of nicotine dependence [13].
Localization (located) of OPRM1 gene associated with addiction and nicotine
11) Confidence 0.67 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1557520 Disease Relevance 0.51 Pain Relevance 1.04
Additionally, the OPRM1 gene is located in a region showing linkage to nicotine dependence.
Localization (located) of OPRM1 gene associated with addiction and nicotine
12) Confidence 0.67 Published 2006 Journal Behav Brain Funct Section Abstract Doc Link PMC1557520 Disease Relevance 1.07 Pain Relevance 0.69
For example, the cannabinoid brain receptor type 1 (CB1) and mu opioid receptor type 1 (MOR1) co-localize in the same presynaptic nerve terminals and signal through a common receptor-mediated G-protein pathway.
Localization (localize) of MOR1 in nerve associated with cannabinoid and mu opioid receptor
13) Confidence 0.65 Published 2010 Journal Curr Drug Targets Section Abstract Doc Link 20196742 Disease Relevance 0.29 Pain Relevance 1.19
In this study, we determined the effect of PLD2 activity on the desensitization and resensitization rate of the mu-opioid receptor.
Localization (rate) of mu-opioid receptor associated with opioid receptor
14) Confidence 0.62 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14720217 Disease Relevance 0 Pain Relevance 0.57
Confocal immunofluorescence microscopy revealed that the opioid precursor POMC colocalizes with its active peptide END, key processing enzymes and MOR in alveolar macrophages, submucosal glands, cancerous cells, and pulmonary neuroendocrine cells within the bronchial epithelium.
Localization (colocalizes) of MOR in neuroendocrine cells associated with opioid receptor and opioid
15) Confidence 0.61 Published 2010 Journal Pharmacol Rep Section Abstract Doc Link 20360624 Disease Relevance 0.33 Pain Relevance 0.96
The cascade starts with abrupt downregulation of mu opiate receptor activity together with elevation of gamma-aminobutyric acid (GABA) and dynorphin release in the striatum and the limbic system [19].
Localization (release) of mu opiate receptor in striatum associated with gaba, dynorphin, opioid receptor 1 and limbic system
16) Confidence 0.61 Published 2006 Journal BMC Psychiatry Section Body Doc Link PMC1489929 Disease Relevance 0.66 Pain Relevance 1.24
Ethanol affects MOP mobility and the plasma membrane lipid dynamics, hinting at MOP release from micro-domains and redistribution at the plasma membrane.
Localization (release) of MOP in plasma associated with opioid receptor
17) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2602977 Disease Relevance 0.10 Pain Relevance 0.51
To study the 5' regulatory region of the human MOR gene (hMOR), we further investigated our previous finding of two regulatory regions and have localized a 40-bp positive cis-acting element and a 35-bp negative cis-acting element that regulate hMOR transcription in SK-N-SH cells.
Localization (localized) of hMOR in SK-N-SH associated with mu opioid receptor
18) Confidence 0.59 Published 2001 Journal DNA Cell Biol. Section Abstract Doc Link 11506703 Disease Relevance 0.27 Pain Relevance 0.58
For example, the cannabinoid brain receptor type 1 (CB1) and mu opioid receptor type 1 (MOR1) co-localize in the same presynaptic nerve terminals and signal through a common receptor-mediated G-protein pathway.
Localization (localize) of mu opioid receptor type 1 in nerve associated with cannabinoid and mu opioid receptor
19) Confidence 0.57 Published 2010 Journal Curr Drug Targets Section Abstract Doc Link 20196742 Disease Relevance 0.29 Pain Relevance 1.19
Anti-MOR sera recognizing the carboxyl terminal domain of MOR was localized using immunoperoxidase and immunogold-silver methods. mu-opioid receptor-like immunoreactivity (MOR-LI) was observed mainly in the superficial layers of the dorsal horn.
Localization (localized) of Anti-MOR in dorsal horn associated with dorsal horn, mu opioid receptor and opioid receptor
20) Confidence 0.57 Published 1996 Journal Brain Res. Section Abstract Doc Link 8883864 Disease Relevance 0 Pain Relevance 1.62

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