INT156404

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 4.06
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Pttg1) chromosome organization (Pttg1) chromosome segregation (Pttg1)
nucleus (Pttg1) cell cycle (Pttg1) cell division (Pttg1)
Anatomy Link Frequency
pituitary 2
Pttg1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 100.00 Very High Very High Very High
agonist 21 95.80 Very High Very High Very High
Dopamine 90 95.48 Very High Very High Very High
headache 4 77.84 Quite High
dopamine receptor 6 71.72 Quite High
Disease Link Frequency Relevance Heat
Pituitary Cancer 80 100.00 Very High Very High Very High
Targeted Disruption 66 99.80 Very High Very High Very High
Cancer 70 98.68 Very High Very High Very High
Hyperplasia 33 95.16 Very High Very High Very High
Pituitary Apoplexy 4 93.72 High High
Prolactinoma 126 92.88 High High
Galactorrhea 18 87.12 High High
Stroke 2 85.36 High High
Headache 4 77.84 Quite High
Scotoma 4 69.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, abundant and concordant PTTG and bFGF expression in different human pituitary tumors was described [4].
Negative_regulation (described) of PTTG in pituitary associated with pituitary cancer
1) Confidence 0.23 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.91 Pain Relevance 0.12
When compared to female wild-type mice, pituitaries from female D2R knockout mice had decreased PTTG concentration (normalized to actin content, Figure 1A, P = 0.00057), while no differences in pttg mRNA expression were found (normalized to the housekeeping gene GAPDH, Figure 1B).
Negative_regulation (decreased) of PTTG associated with targeted disruption
2) Confidence 0.20 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.07 Pain Relevance 0.19
When compared to female wild-type mice, pituitaries from female D2R knockout mice had decreased PTTG concentration, while no difference in pttg mRNA level was found.
Negative_regulation (decreased) of PTTG associated with targeted disruption
3) Confidence 0.20 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1779802 Disease Relevance 1.00 Pain Relevance 0.13
Immunohistochemical analysis was used to define the different hormone types of the tumors and the expression of various immunologic targets, including the pituitary tumor transforming gene, basic fibroblast growth factor-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and proliferating cell nuclear antigen.
Negative_regulation (inhibitor) of pituitary tumor transforming in pituitary associated with cancer, pituitary cancer and metalloproteinase
4) Confidence 0.03 Published 2009 Journal J Clin Neurosci Section Abstract Doc Link 19046883 Disease Relevance 1.08 Pain Relevance 0.18

General Comments

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