INT156410

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.51
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdgfra) nucleus (Pdgfra) extracellular matrix organization (Pdgfra)
kinase activity (Pdgfra) cytoplasm (Pdgfra)
Anatomy Link Frequency
platelet 2
Pdgfra (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 6 81.96 Quite High
pain pelvic 1 81.60 Quite High
nMDA receptor 62 75.00 Quite High
methotrexate 1 66.56 Quite High
cINOD 5 58.00 Quite High
depression 16 5.00 Very Low Very Low Very Low
long-term potentiation 10 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Pyramidal cell 4 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 40 99.76 Very High Very High Very High
Disease 7 92.12 High High
Reprotox - General 3 2 89.24 High High
Desmoid Disease 27 83.60 Quite High
Gastrointestinal Stromal Tumor 3 78.12 Quite High
Fibroma 14 50.00 Quite Low
Toxicity 2 35.12 Quite Low
Depression 16 5.00 Very Low Very Low Very Low
Recurrence 12 5.00 Very Low Very Low Very Low
Leukemia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect is presumably due to tumor expression of activated receptor tyrosine kinases c-kit and/or platelet-derived growth factor receptor-alpha (PDGFRA).
Positive_regulation (activated) of platelet-derived growth factor receptor-alpha in platelet associated with cancer
1) Confidence 0.08 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2438440 Disease Relevance 0.73 Pain Relevance 0.09
The tumor cells were positive for KIT, CD34, platelet-derived growth factor receptor alpha, and vimentin, but negative for alpha-smooth muscle actin, S100 protein, p53 protein, HMB45, and desmin.
Positive_regulation (positive) of platelet-derived growth factor receptor alpha in platelet associated with cancer
2) Confidence 0.04 Published 2009 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 19047911 Disease Relevance 0.78 Pain Relevance 0.12
PDGF receptor activation decreases the cytoplasmic pool of Abl kinase
Positive_regulation (activation) of PDGF receptor
3) Confidence 0.01 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0
We have previously demonstrated that PDGF receptor activation indirectly inhibits N-methyl-D-aspartate (NMDA) currents by modifying the cytoskeleton.
Positive_regulation (activation) of PDGF receptor
4) Confidence 0.01 Published 2008 Journal Mol Brain Section Abstract Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.04

General Comments

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