INT156411

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 5.50
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdgfra) nucleus (Pdgfra) extracellular matrix organization (Pdgfra)
kinase activity (Pdgfra) cytoplasm (Pdgfra)
Anatomy Link Frequency
platelet 3
brain 1
Pdgfra (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 6 81.96 Quite High
pain pelvic 1 81.60 Quite High
methotrexate 1 66.56 Quite High
abdominal pain 1 61.12 Quite High
cINOD 5 58.56 Quite High
cva 1 56.96 Quite High
Central nervous system 15 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 284 99.98 Very High Very High Very High
Glioma 135 96.92 Very High Very High Very High
Neurilemmoma 1 95.12 Very High Very High Very High
Neurofibroma 1 94.08 High High
Disease 16 92.68 High High
Reprotox - General 3 2 89.24 High High
Gastrointestinal Stromal Tumor 12 88.72 High High
Desmoid Disease 27 83.60 Quite High
Severe Combined Immunodeficiency 8 82.64 Quite High
Brain Tumor 180 80.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although their overall incidence is low, GISTs are distinctive subgroup of gastrointestinal mesenchymal tumors which express CD117 or platelet derived growth factor receptor alpha (PDGFRA).
Gene_expression (express) of platelet derived growth factor receptor alpha in platelet associated with cancer
1) Confidence 0.75 Published 2010 Journal Chirurgia (Bucur) Section Abstract Doc Link 20941986 Disease Relevance 1.31 Pain Relevance 0.09
A previous report described a significant association between PDGFRA expression, as analyzed at the mRNA level by in situ hybridization and LOH17p in human gliomas [132].
Gene_expression (expression) of PDGFRA associated with glioma
2) Confidence 0.64 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.79 Pain Relevance 0
-positive precursors in the brain and/or for upregulation of Pdgfra expression at the promoter level.
Gene_expression (expression) of Pdgfra in brain
3) Confidence 0.64 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.44 Pain Relevance 0
The model was created to mimic human secondary GBs characterized by combined PDGFRA overexpression/amplification and TP53 deletion/mutation, and results did prove that this combination is instrumental in generating GBs.
Gene_expression (overexpression) of PDGFRA
4) Confidence 0.49 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.74 Pain Relevance 0
Despite the relatively high transcript levels of PDGFRa, Tie2, c-kit, CD59, CD63, CD44 and CD24 in RoSH and E-RoSH cells, they were not immunoreactive against PDGFRa, Tie2, c-kit, CD59, CD63, CD44 and CD24 (data not shown).
Gene_expression (levels) of PDGFRa
5) Confidence 0.44 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.25 Pain Relevance 0
Despite the relatively high transcript levels of PDGFRa, Tie2, c-kit, CD59, CD63, CD44 and CD24 in RoSH and E-RoSH cells, they were not immunoreactive against PDGFRa, Tie2, c-kit, CD59, CD63, CD44 and CD24 (data not shown).
Neg (not) Gene_expression (immunoreactive) of PDGFRa
6) Confidence 0.38 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.24 Pain Relevance 0
Expression of endothelial genes such as Flk-1, Kit, Pdgfra and Tek was also increased with increased immunoreactivity against the gene products (fig. 3g).
Gene_expression (Expression) of Pdgfra
7) Confidence 0.34 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.22 Pain Relevance 0
Pdgfra and Tie-2 did not produce detectable levels of protein product.
Neg (not) Gene_expression (produce) of Pdgfra
8) Confidence 0.30 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0 Pain Relevance 0
The tumor cells were positive for KIT, CD34, platelet-derived growth factor receptor alpha, and vimentin, but negative for alpha-smooth muscle actin, S100 protein, p53 protein, HMB45, and desmin.
Neg (negative) Gene_expression (positive) of platelet-derived growth factor receptor alpha in platelet associated with cancer
9) Confidence 0.14 Published 2009 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 19047911 Disease Relevance 0.78 Pain Relevance 0.12
This effect is presumably due to tumor expression of activated receptor tyrosine kinases c-kit and/or platelet-derived growth factor receptor-alpha (PDGFRA).
Gene_expression (expression) of platelet-derived growth factor receptor-alpha in platelet associated with cancer
10) Confidence 0.13 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2438440 Disease Relevance 0.73 Pain Relevance 0.09

General Comments

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