INT156416

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 38
Total Number 39
Disease Relevance 18.35
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lipg) extracellular space (Lipg) extracellular region (Lipg)
lipid metabolic process (Lipg)
Anatomy Link Frequency
muscles 5
EDL 2
hepatocytes 1
gum 1
limb muscles 1
Lipg (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 97 100.00 Very High Very High Very High
Inflammation 632 99.56 Very High Very High Very High
Arthritis 122 99.52 Very High Very High Very High
agonist 111 99.32 Very High Very High Very High
antagonist 24 99.32 Very High Very High Very High
COX-2 inhibitor 21 99.08 Very High Very High Very High
Antihyperalgesic 1 97.40 Very High Very High Very High
Hyperalgesia 2 96.52 Very High Very High Very High
Bile 21 94.92 High High
Inflammatory mediators 92 94.32 High High
Disease Link Frequency Relevance Heat
Obesity 157 99.98 Very High Very High Very High
Disorder Of Lipid Metabolism 323 99.96 Very High Very High Very High
Pancreatitis 303 99.96 Very High Very High Very High
INFLAMMATION 725 99.56 Very High Very High Very High
Arthritis 285 99.52 Very High Very High Very High
Injury 85 98.88 Very High Very High Very High
Hypertrophy 33 98.52 Very High Very High Very High
Stress 160 98.24 Very High Very High Very High
Targeted Disruption 211 98.02 Very High Very High Very High
Hyperalgesia 2 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both DL and MeDL produced a marked improvement in the motility and stair climbing ability of the rats.
Gene_expression (produced) of MeDL
1) Confidence 0.67 Published 2009 Journal Phytother Res Section Abstract Doc Link 19048609 Disease Relevance 0.82 Pain Relevance 0.46
The gastrocnemius and EDL muscles showed a similar degree of injury in all groups.


Gene_expression (muscles) of EDL in gastrocnemius associated with injury
2) Confidence 0.40 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074344 Disease Relevance 0.53 Pain Relevance 0
To decipher the molecular basis of Kit-dependent steatosis, we determined the expression profiles of key genes involved in lipid hepatic metabolism: such as apoliproteins (Apoa1, ApoB), lipoprotein receptors (LdlR, VldlR, Scarb1, Lrp1), lipase (Lipc, LipH, Lpl) and others implicated in hepatic lipidogenesis (Scap, Srebf1, Srebf2), lipid secretion (Pltp, Mttp, Abca1), bile acid synthesis (Cyp8b1, Cyp7a1), lipid transport (Slc10a1, Abcb11, Abcb1a, Abcc2) and a lipodystrophy gene, Lipin 1 (Lpin1), encoding a phosphatidate phosphatase enzyme with transcription activity [26-28].
Spec (determined) Gene_expression (expression) of lipase in bile associated with bile and lipodystrophy
3) Confidence 0.39 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.16 Pain Relevance 0.05
Levels of amylase, lipase, creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubine and alkaline phosphatase were measured by a veterinary clinical laboratory using standard laboratory techniques.
Gene_expression (Levels) of lipase
4) Confidence 0.24 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.26 Pain Relevance 0.07
However, although the maximal response of the EDL was unaltered, there was a right shift in the curve suggesting impaired insulin-stimulated phosphorylation of PKB (Figure S2).


Gene_expression (response) of EDL
5) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.30 Pain Relevance 0
Serum levels of amylase, lipase and cytokines (MCP-1, IL-6) were monitored and the histological appearance of the tissue was investigated.
Gene_expression (levels) of lipase associated with cytokine
6) Confidence 0.16 Published 2006 Journal BMC Gastroenterol Section Abstract Doc Link PMC1637108 Disease Relevance 0.52 Pain Relevance 0.05
After induction of pancreatitis, levels of lipase (after 24 hours) and amylase (after 48 hours) were higher in R122H mice compared to controls.
Gene_expression (levels) of lipase associated with pancreatitis
7) Confidence 0.16 Published 2006 Journal BMC Gastroenterol Section Abstract Doc Link PMC1637108 Disease Relevance 0.96 Pain Relevance 0.08
However, the slightly higher serum levels of lipase and amylase (figure 2) suggests a subtle acinar damage that is not reflected by histological changes.
Gene_expression (levels) of lipase
8) Confidence 0.16 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1637108 Disease Relevance 0.96 Pain Relevance 0.12
We found widespread micro-dystrophin expression in the TA and EDL at 1, 2, and 3 months post gene transfer (Fig. 1B), with insignificant differences in quantitation of transduced myofibers (rAAV8 > 90% and rAAV6 > 80%).
Gene_expression (expression) of EDL
9) Confidence 0.15 Published 2007 Journal J Transl Med Section Body Doc Link PMC2082019 Disease Relevance 0.12 Pain Relevance 0
We measured the specific isometric force of untreated EDL and TA muscles of 8 week-old myotubularin-deficient mice and found that strength was lower by ?
Gene_expression (force) of EDL in EDL
10) Confidence 0.15 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.28 Pain Relevance 0.03
The transgenic animals did not develop a spontaneous pancreatitis, although we observed slightly higher baseline levels of amylase and lipase.
Gene_expression (levels) of lipase associated with targeted disruption and pancreatitis
11) Confidence 0.14 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1637108 Disease Relevance 0.81 Pain Relevance 0.03
The electrophysiological studies show that ghrelin can inhibit the excitatory inputs in the parvocellular neurons of the PVN and that this effect can be abolished by administration of a CB1 antagonist or THL, an inhibitor of the 2-AG synthesizing enzyme DAG lipase.
Gene_expression (synthesizing) of lipase in neurons associated with antagonist
12) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.15 Pain Relevance 0.32
agonist Wy14643 modestly induced hepatic lipase (Lipc) expression in primary human hepatocytes [24].
Gene_expression (expression) of lipase in hepatocytes associated with agonist
13) Confidence 0.14 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.47 Pain Relevance 0.10
Both limb muscles exhibited an increase in muscle fiber size without a change in fiber number, with the exception of the EDL in the mdx 11H group, which did not hypertrophy (Figs. 5, 6).
Neg (exception) Gene_expression (exception) of EDL in limb muscles associated with hypertrophy
14) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.41 Pain Relevance 0
Widespread micro-dystrophin expression was observed in the TA and EDL muscles of mice receiving rAAV6 and rAAV8 at all three time points (Fig. 1B).
Gene_expression (muscles) of EDL in muscles
15) Confidence 0.13 Published 2007 Journal J Transl Med Section Body Doc Link PMC2082019 Disease Relevance 0.23 Pain Relevance 0
Both MeDL and rofecoxib produced a
Gene_expression (produced) of MeDL
16) Confidence 0.11 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1852887 Disease Relevance 0.64 Pain Relevance 0.04
Both MeDL and rofecoxib produced a dose-dependent
Gene_expression (produced) of MeDL
17) Confidence 0.11 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1852887 Disease Relevance 0.63 Pain Relevance 0.03
MeDL produced a dose-dependent
Gene_expression (produced) of MeDL
18) Confidence 0.11 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1852887 Disease Relevance 1.09 Pain Relevance 0.45
Both MeDL and rofecoxib produced a significant
Gene_expression (produced) of MeDL
19) Confidence 0.10 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1852887 Disease Relevance 0.52 Pain Relevance 0.23
The MeDL was triturated with gum acacia
Gene_expression (triturated) of MeDL in gum
20) Confidence 0.10 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1852887 Disease Relevance 0.31 Pain Relevance 0.11

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