INT156427

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Context Info
Confidence 0.73
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.36
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (FOXC1) nucleus (FOXC1) DNA binding (FOXC1)
transcription factor binding (FOXC1) cytoplasm (FOXC1)
FOXC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 9 100.00 Very High Very High Very High
Inflammation 68 99.98 Very High Very High Very High
methotrexate 6 99.70 Very High Very High Very High
Cauda equina syndrome 1 96.08 Very High Very High Very High
Spinal cord 2 93.08 High High
cytokine 80 90.88 High High
corticosteroid 5 81.24 Quite High
Central nervous system 3 70.56 Quite High
Inflammatory response 4 60.08 Quite High
Crohn's disease 14 26.80 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 70 99.98 Very High Very High Very High
Drug Induced Neurotoxicity 1 97.40 Very High Very High Very High
Polyradiculopathy 1 96.08 Very High Very High Very High
Paraplegia 1 95.00 High High
Quadriplegia 1 94.52 High High
Encephalopathy 2 92.56 High High
Convulsion 2 91.76 High High
Hematologic Neoplasms 3 75.00 Quite High
Lymphatic System Cancer 1 69.64 Quite High
Leukemia 1 68.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is mostly related to combined IT methotrexate and Ara-C, or Ara-C as the sole IT agent when given at high doses or as a slow-release preparation.
Localization (release) of Ara associated with methotrexate and intrathecal
1) Confidence 0.73 Published 2009 Journal Ann. Hematol. Section Abstract Doc Link 19050889 Disease Relevance 1.03 Pain Relevance 0.82
Therefore, we fully agree that in an in vivo situation pro-inflammatory effects of ARA are probably mediated by eicosanoids synthesized from ARA, however, these effects are not derived from a direct eicosanoid mediated activation of NF-?
Localization (effects) of ARA associated with inflammation
2) Confidence 0.11 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.24 Pain Relevance 0.12
B activity and the role of cyclooxygenase (COX)-enzymes, the experiments with the fatty acids ARA and EPA were repeated but now in our NF-?
Localization (repeated) of ARA
3) Confidence 0.11 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.09 Pain Relevance 0.13

General Comments

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