INT15643

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Context Info
Confidence 0.65
First Reported 1983
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 30
Total Number 33
Disease Relevance 4.59
Pain Relevance 15.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
plasma 15
anterior pituitary 12
pituitary 8
spinal cord 2
supraoptic nucleus 2
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 14 100.00 Very High Very High Very High
Dynorphin 8 100.00 Very High Very High Very High
opiate 7 100.00 Very High Very High Very High
antagonist 52 99.96 Very High Very High Very High
alcohol 52 99.84 Very High Very High Very High
Endogenous opioid 22 99.80 Very High Very High Very High
agonist 34 99.78 Very High Very High Very High
Morphine 33 99.78 Very High Very High Very High
Opioid 36 99.74 Very High Very High Very High
Hippocampus 20 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 80 100.00 Very High Very High Very High
Shock 3 99.32 Very High Very High Very High
Sprains And Strains 5 98.92 Very High Very High Very High
Alcohol Addiction 6 97.44 Very High Very High Very High
Pressure And Volume Under Development 11 93.44 High High
Disease 3 93.20 High High
Pain 13 91.72 High High
INFLAMMATION 36 91.48 High High
Demyelinating Disease 1 75.48 Quite High
Multiple Sclerosis 1 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that the GnRH gene is fully expressed well before the time of normal puberty onset and that the increase in POMC mRNA that occurs with the onset of puberty may be important for the development of pulsatile GnRH secretion.
Spec (may) Positive_regulation (important) of Positive_regulation (increase) of POMC mRNA
1) Confidence 0.65 Published 1989 Journal Endocrinology Section Abstract Doc Link 2647464 Disease Relevance 0.05 Pain Relevance 0.19
Thus, increased inactivation of beta-endorphin may contribute to the attenuation of the opioid inhibition of luteinizing hormone secretion observed during puberty.
Positive_regulation (increased) of Positive_regulation (inactivation) of beta-endorphin associated with opioid
2) Confidence 0.50 Published 1985 Journal Neuroscience Section Abstract Doc Link 2936981 Disease Relevance 0 Pain Relevance 0.36
There was an increase in the number of beta-endorphin-immunoreactive cells in the arcuate nucleus and an increase in the density of beta-endorphin fibres within the supraoptic nucleus and peri-supraoptic region in late pregnancy and parturition, suggesting enhanced expression of beta-endorphin and increased beta-endorphin innervation of the supraoptic nucleus.
Positive_regulation (increased) of Positive_regulation (innervation) of beta-endorphin in supraoptic nucleus
3) Confidence 0.50 Published 2002 Journal J. Neuroendocrinol. Section Abstract Doc Link 12372001 Disease Relevance 0 Pain Relevance 0.07
While a few studies observed an increase in the level of beta-endorphin after a single fluoxetine injection, we did not observe any increase in beta-endorphin plasma levels after repeated fluoxetine treatment.
Positive_regulation (increase) of Positive_regulation (increase) of beta-endorphin in plasma associated with fluoxetine
4) Confidence 0.50 Published 2008 Journal Pharmazie Section Abstract Doc Link 18468392 Disease Relevance 0.07 Pain Relevance 1.13
However, high intramuscular concentrations of endorphin corresponded to a sustained secretion of ?
Positive_regulation (corresponded) of Positive_regulation (concentrations) of endorphin
5) Confidence 0.50 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400409 Disease Relevance 0.60 Pain Relevance 0.38
However, the de novo biosynthesis of beta-endorphin and its prohormones beta-lipotropin and pro-opiomelanocortin was increased in the intermediate pituitary and to an even more pronounced degree, in the adenohypophysis, after chronic treatment of rats with ethanol liquid diet, nevertheless, the amounts of opiate-active beta-endorphin were found to be reduced in both lobes of the pituitary: In the adenohypophysis, this was due to a retardation of the enzymatic processing of beta-endorphin from its precursor beta-lipotropin, while in the intermediate pituitary the alpha-N-acetylation of beta-endorphin to opiate-inactive alpha-N-acetyl-beta-endorphin was stimulated.
Positive_regulation (stimulated) of Positive_regulation (alpha-N-acetylation) of beta-endorphin in adenohypophysis associated with opiate
6) Confidence 0.49 Published 1983 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6138772 Disease Relevance 0 Pain Relevance 0.68
The employed stress paradigm also induced an elevation of anterior pituitary levels of PRL and POMC mRNAs.
Positive_regulation (induced) of Positive_regulation (induced) of POMC in anterior pituitary associated with stress
7) Confidence 0.49 Published 1994 Journal Peptides Section Abstract Doc Link 7984495 Disease Relevance 0.63 Pain Relevance 0.42
Recurrent exposure to intermittent electrical foot-shock (30 min, twice daily) for 7 days caused an increase in immunoreactive (ir) dynorphin and ir-alpha-neo-endorphin in lumbar and cervical (but not thoracic) spinal cord as measured 16 h following the final session.
Positive_regulation (caused) of Positive_regulation (increase) of ir-alpha-neo-endorphin in spinal cord associated with dynorphin, shock and spinal cord
8) Confidence 0.47 Published 1987 Journal Brain Res. Section Abstract Doc Link 2886190 Disease Relevance 0.26 Pain Relevance 0.46
A single injection of ethanol also results in the increase of beta-endorphin level.
Positive_regulation (results) of Positive_regulation (increase) of beta-endorphin
9) Confidence 0.47 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16009491 Disease Relevance 0.09 Pain Relevance 0.11
After 7 days of swim training, 4 hours of swimming caused a slight increase of alpha-, beta- and gamma-endorphin levels in hypophysis as well as a pronounced increase of alpha- and beta-endorphins in adrenals.
Positive_regulation (caused) of Positive_regulation (increase) of gamma-endorphin in hypophysis
10) Confidence 0.46 Published 1991 Journal Int J Sports Med Section Abstract Doc Link 1752719 Disease Relevance 0 Pain Relevance 0.07
It was observed that voluntary alcohol intake induces an increase in plasma beta-endorphin levels in WHP rats.
Positive_regulation (induces) of Positive_regulation (increase) of beta-endorphin in plasma associated with alcohol
11) Confidence 0.46 Published 2008 Journal Physiol. Behav. Section Abstract Doc Link 18262210 Disease Relevance 0.10 Pain Relevance 0.83
It is well known that alcohol consumption leads to an increase in the levels of beta-endorphin (an endogenous opioid), which can contribute to the reinforcing effect of alcohol.
Positive_regulation (leads) of Positive_regulation (increase) of beta-endorphin associated with endogenous opioid and alcohol
12) Confidence 0.46 Published 2008 Journal Physiol. Behav. Section Abstract Doc Link 18262210 Disease Relevance 0 Pain Relevance 0.49
Our previous studies have shown that repeated treatment with naltrexone, a nonselective opioid antagonist, results in increased plasma beta-endorphin levels.
Positive_regulation (results) of Positive_regulation (increased) of beta-endorphin in plasma associated with antagonist and opioid
13) Confidence 0.46 Published 2008 Journal Physiol. Behav. Section Abstract Doc Link 18262210 Disease Relevance 0.06 Pain Relevance 0.62
In sharp contrast to proenkephalin RNA, the abundance of POMC RNA remained relatively constant throughout the estrous cycle in both tissues.
Positive_regulation (constant) of Positive_regulation (abundance) of POMC RNA
14) Confidence 0.46 Published 1988 Journal Endocrinology Section Abstract Doc Link 3345721 Disease Relevance 0 Pain Relevance 0.14
Chronic treatment of rats with morphine by implantation of pellets over a period of 10 days resulted in a differential alteration of pro-opiomelanocortin (POMC) mRNA levels in individual pituitary lobes: Hybridisation studies using a 32P-labelled mouse POMC cDNA fragment of 150 bases as a probe revealed that chronic morphine treatment causes about 50% enhancement of POMC mRNA levels in the anterior lobe and about 40% decrease in the intermediate lobe of the pituitary.
Positive_regulation (causes) of Positive_regulation (enhancement) of POMC mRNA in pituitary associated with morphine
15) Confidence 0.45 Published 1985 Journal Neuropeptides Section Abstract Doc Link 4000418 Disease Relevance 0 Pain Relevance 0.35
However, the de novo biosynthesis of beta-endorphin and its prohormones beta-lipotropin and pro-opiomelanocortin was increased in the intermediate pituitary and to an even more pronounced degree, in the adenohypophysis, after chronic treatment of rats with ethanol liquid diet, nevertheless, the amounts of opiate-active beta-endorphin were found to be reduced in both lobes of the pituitary: In the adenohypophysis, this was due to a retardation of the enzymatic processing of beta-endorphin from its precursor beta-lipotropin, while in the intermediate pituitary the alpha-N-acetylation of beta-endorphin to opiate-inactive alpha-N-acetyl-beta-endorphin was stimulated.
Positive_regulation (stimulated) of Positive_regulation (alpha-N-acetylation) of beta-endorphin in adenohypophysis associated with opiate
16) Confidence 0.43 Published 1983 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6138772 Disease Relevance 0 Pain Relevance 0.68
Treatment with acamprosate in dose 200mg/kg, p.o. for 10 days induced an increase in plasma beta-endorphin levels.
Positive_regulation (induced) of Positive_regulation (increase) of beta-endorphin in plasma
17) Confidence 0.41 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16009491 Disease Relevance 0.10 Pain Relevance 0.10
These results indicate a possible role for increased levels of NAS beta-endorphin in the organism's adaptive response to stress and frustration.
Spec (possible) Positive_regulation (role) of Spec (possible) Positive_regulation (increased) of beta-endorphin in NAS associated with stress and nucleus accumbens
18) Confidence 0.39 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12653982 Disease Relevance 0.10 Pain Relevance 0.41
Taken together, the increase of plasma beta-endorphin by agmatine in STZ rats through activation of imidazoline I(2)R was mainly induced by the I(2A) subtype located in adrenal gland.
Positive_regulation (induced) of Positive_regulation (increase) of beta-endorphin in adrenal gland
19) Confidence 0.38 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 19913596 Disease Relevance 0.07 Pain Relevance 0.28
Prazosin alone had no effect on the ether-induced plasma ACTH and beta-endorphin elevation.
Positive_regulation (ether-induced) of Positive_regulation (elevation) of beta-endorphin in plasma
20) Confidence 0.37 Published 1999 Journal Psychoneuroendocrinology Section Abstract Doc Link 10101737 Disease Relevance 0.42 Pain Relevance 0.65

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