INT156436

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.62
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DLGAP3) cell-cell signaling (DLGAP3)
Anatomy Link Frequency
striatum 2
DLGAP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 1 97.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Congenital Anomalies 1 98.68 Very High Very High Very High
Anxiety Disorder 6 97.88 Very High Very High Very High
Impulse Control Disorders 1 77.76 Quite High
Obsessive-compulsive Disorder 1 74.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent study found that mice with a deletion of the Sapap3 gene groomed themselves excessively, exhibited increased anxiety-like behaviors, and had cortico-striatal synaptic defects, all of which were preventable with lentiviral-mediated expression of Sapap3 in the striatum; the behavioral abnormalities were also reversible with fluoxetine.
Positive_regulation (mediated) of Gene_expression (expression) of Sapap3 in striatum associated with congenital anomalies, anxiety disorder and fluoxetine
1) Confidence 0.50 Published 2009 Journal Am. J. Med. Genet. B Neuropsychiatr. Genet. Section Abstract Doc Link 19051237 Disease Relevance 0.62 Pain Relevance 0.10

General Comments

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