INT156438

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Context Info
Confidence 0.14
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.24
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cpox, Nos2) oxidoreductase activity (Cpox, Nos2) mitochondrion (Cpox)
peroxisome (Nos2) intracellular (Nos2) cytosol (Nos2)
Anatomy Link Frequency
peritoneal macrophages 1
Cpox (Mus musculus)
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 29 99.48 Very High Very High Very High
headache 1 83.04 Quite High
cytokine 22 59.28 Quite High
Inflammatory mediators 3 36.56 Quite Low
COX2 1 25.00 Low Low
Inflammatory response 6 14.64 Low Low
cINOD 22 5.00 Very Low Very Low Very Low
COX-2 inhibitor 14 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 45 99.48 Very High Very High Very High
Cancer 79 96.48 Very High Very High Very High
Metastasis 5 95.12 Very High Very High Very High
Necrosis 4 90.64 High High
Headache 1 83.04 Quite High
Malignant Neoplastic Disease 1 28.84 Quite Low
Pancreatitis 1 23.92 Low Low
Nicotine Addiction 1 20.04 Low Low
Pancreatic Cancer 84 19.40 Low Low
Apoptosis 39 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During the inflammatory process, cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) were increased in mouse peritoneal macrophages.
COX Positive_regulation (inducible) of iNOS in peritoneal macrophages associated with inflammation
1) Confidence 0.14 Published 2008 Journal Am. J. Chin. Med. Section Abstract Doc Link 19051342 Disease Relevance 0.52 Pain Relevance 0.28
In response to LPS, COX-2-/- mice showed a higher increase in iNOS mRNA levels compared to COX-2+/+ mice (Fig. 5A).
COX Positive_regulation (increase) of iNOS
2) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.09 Pain Relevance 0.05
Furthermore, iNOS is induced by COX-2 and there is a significant correlation between positive COX-2 and iNOS expression in cancer tissues [125,126].
COX Positive_regulation (induced) of iNOS associated with cancer
3) Confidence 0.02 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.62 Pain Relevance 0.07

General Comments

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