INT156462

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) nucleoplasm (Creb1) mitochondrion (Creb1)
DNA binding (Creb1) cytoplasm (Ephb1) signal transduction (Ephb1)
Anatomy Link Frequency
amygdala 1
Creb1 (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 9 98.26 Very High Very High Very High
amygdala 6 98.04 Very High Very High Very High
withdrawal 4 77.20 Quite High
opiate 2 75.00 Quite High
alcohol 1 66.68 Quite High
cocaine 1 65.16 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The progressive increase in low-dose (3 mg/kg) morphine CPP was associated with increased ERK phosphorylation (a measure of ERK activity) and CREB (a downstream target of ERK) phosphorylation in central but not basolateral amygdala.
CREB Regulation (target) of ERK in amygdala associated with amygdala and morphine
1) Confidence 0.29 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19052216 Disease Relevance 0 Pain Relevance 1.07

General Comments

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