INT156464

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.90
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
neurons 1
band 1


Pain Term Frequency Confidence Heat
Kinase C 6 100.00 Very High Very High Very High
Glutamate 48 100.00 Very High Very High Very High
Visceral pain 3 98.48 Very High Very High Very High
Pain 15 96.76 Very High Very High Very High
Spinal cord 19 84.40 Quite High
nociceptor 11 84.28 Quite High
Neurotransmitter 14 82.88 Quite High
Dorsal horn neuron 11 81.92 Quite High
nMDA receptor 19 80.48 Quite High
agonist 103 75.36 Quite High
Disease Term Frequency Confidence Heat
[[ /

[[]]]]

3 98.48 Very High Very High Very High
Pain 12 96.76 Very High Very High Very High
Diabetic Cardiomyopathies 2 96.48 Very High Very High Very High
Diabetes Mellitus 56 92.72 High High
Hyperglycemia 2 89.92 High High
Stress 27 83.04 Quite High
Injury 5 71.56 Quite High
INFLAMMATION 23 65.64 Quite High
Coronary Heart Disease 4 64.88 Quite High
Cv General 3 Under Development 1 64.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This unusual enhancement occurred via a direct modulation of glutamate release involving protein kinase A (PKA) and PKC (Evans et al., 2001), and was evidenced by an increase in the frequency of sEPSCs.
Regulation (modulation) of PKC associated with glutamate
1) Confidence 0.60 Published 2007 Journal Neuroscience Section Body Doc Link PMC2504724 Disease Relevance 0 Pain Relevance 0.23
Of interest, the central portion of the dense band of PKC?
Regulation (portion) of PKC in band
2) Confidence 0.44 Published 2006 Journal Mol Pain Section Body Doc Link PMC1479315 Disease Relevance 0.06 Pain Relevance 0.38
This process is dependent on protein kinase C (PKC) activation [37,38].
Regulation (dependent) of PKC associated with kinase c
3) Confidence 0.44 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570581 Disease Relevance 1.22 Pain Relevance 0.08
The mechanism of modulation of the PLC/PKC/InsP3 system by ?
Regulation (modulation) of PKC
4) Confidence 0.44 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701284 Disease Relevance 0 Pain Relevance 0.29
Furthermore, we show that modulation of the Ca(2+) channels or protein kinase C (PKC), a downstream molecule of PLCbeta4, altered the firing modes of TC neurons and pain responses in the predicted ways.
Regulation (modulation) of PKC in neurons associated with pain and kinase c
5) Confidence 0.26 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19052225 Disease Relevance 0.17 Pain Relevance 0.74
that in turn modulated the activity of the PKC?
Regulation (modulated) of PKC
6) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.18 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox