INT15648

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Context Info
Confidence 0.67
First Reported 1986
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 12.03
Pain Relevance 3.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (RYR1) transmembrane transport (RYR1) cytoplasm (RYR1)
Anatomy Link Frequency
arm 2
skeletal muscle 2
muscle 1
neurons 1
finger 1
RYR1 (Homo sapiens)
RYR1 - D4899Q (2) RYR1 - G4898R (1)
Pain Link Frequency Relevance Heat
Multiple sclerosis 124 99.86 Very High Very High Very High
Paracetamol 4 99.34 Very High Very High Very High
agonist 6 96.80 Very High Very High Very High
5HT 1 96.40 Very High Very High Very High
Serotonin 3 96.20 Very High Very High Very High
anesthesia 34 95.56 Very High Very High Very High
halothane 35 92.24 High High
withdrawal 2 90.56 High High
beta blocker 1 90.00 High High
potassium channel 14 89.84 High High
Disease Link Frequency Relevance Heat
Malignant Hyperthermia 259 100.00 Very High Very High Very High
Contracture 38 99.96 Very High Very High Very High
Muscle Rigidity 19 99.92 Very High Very High Very High
Demyelinating Disease 127 99.86 Very High Very High Very High
Post-traumatic Stress Disorder 27 99.52 Very High Very High Very High
Muscle Disease 16 98.92 Very High Very High Very High
Fever 17 98.64 Very High Very High Very High
Syndrome 28 98.00 Very High Very High Very High
Mental Disorders 123 97.32 Very High Very High Very High
Graves' Ophthalmopathy 60 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intradermal injection of prostaglandin E2 (PGE2; 100 ng), which induced a significant decrease in the mechanical threshold of C-MHs (n = 7), had no effect on the latency of the delayed activation of C-MHs.
Positive_regulation (activation) of MHs
1) Confidence 0.67 Published 1991 Journal J. Neurophysiol. Section Abstract Doc Link 1753283 Disease Relevance 0.23 Pain Relevance 0.45
In contrast, propranolol shifted the caffeine dose-response curve to the right and significantly increased the caffeine threshold in the MHS group.
Positive_regulation (increased) of MHS
2) Confidence 0.60 Published 1989 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 2800978 Disease Relevance 0.59 Pain Relevance 0.21
Several mutations in the ryanodine receptor (RYR1) have been found to be causative of MH.
Positive_regulation (causative) of RYR1 associated with malignant hyperthermia
3) Confidence 0.45 Published 1998 Journal Clin. Genet. Section Abstract Doc Link 9831351 Disease Relevance 0.65 Pain Relevance 0.09
Several mutations in the ryanodine receptor (RYR1) have been found to be causative of MH.
Positive_regulation (causative) of ryanodine receptor associated with malignant hyperthermia
4) Confidence 0.45 Published 1998 Journal Clin. Genet. Section Abstract Doc Link 9831351 Disease Relevance 0.65 Pain Relevance 0.10
Furthermore, we found in our study is that sex did not predispose for MHS use although former studies showed a positive relation for females [9,37].
Neg (not) Positive_regulation (predispose) of MHS
5) Confidence 0.44 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1949813 Disease Relevance 0.09 Pain Relevance 0
These agents can also cause MHS contractures in susceptible muscle [101].
Positive_regulation (cause) of MHS in muscle associated with contracture
6) Confidence 0.44 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 1.33 Pain Relevance 0.19
They showed that (subclinical) PTSD was clearly related to increased use of MHS.
Positive_regulation (increased) of MHS associated with post-traumatic stress disorder
7) Confidence 0.41 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1949813 Disease Relevance 0.50 Pain Relevance 0
A plausible explanation for the higher rates of MHS utilization among this group is that their higher rates of pre-disaster psychological health problems may be indirectly related to increased post-disaster MHS use.
Positive_regulation (increased) of MHS
8) Confidence 0.41 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1949813 Disease Relevance 0.06 Pain Relevance 0
MHS is elicited by all commonly used potent inhalation anesthetics and depolarizing neuromuscular blockers and remains an important cause of death due to anesthesia.
Positive_regulation (elicited) of MHS associated with anesthesia and death
9) Confidence 0.40 Published 1991 Journal Genomics Section Abstract Doc Link 1774061 Disease Relevance 0.46 Pain Relevance 0.09
The L4838V mutation is unique because it is the mutation first found within a hydrophobic transmembrane segment of the channel region and should provide further information on the function of the RyR1 as well as for genetic diagnosis of MH.
Positive_regulation (information) of RyR1 associated with malignant hyperthermia
10) Confidence 0.40 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11928716 Disease Relevance 0.60 Pain Relevance 0.06
Molecu</span>lar dynamics <span style="background-color:#B0E0E6">simulations of RyR1-G4898R and RyR1-D4899Q
Positive_regulation (simulations) of RyR1-D4899Q (D4899Q)
11) Confidence 0.32 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2668181 Disease Relevance 0 Pain Relevance 0
Molecular dynamics simulations of RyR1-G4898R and RyR1-D4899Q
Positive_regulation (simulations) of RyR1-G4898R (G4898R)
12) Confidence 0.32 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2668181 Disease Relevance 0 Pain Relevance 0
In simulations of RyR1-D4899Q, the RDFs and ion histogram taken together prove that Ca2+ and K+ bind only at the end of the selectivity filter especially near E4900.
Positive_regulation (simulations) of RyR1-D4899Q (D4899Q)
13) Confidence 0.32 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2668181 Disease Relevance 0 Pain Relevance 0
In six MHS pigs, oxygen consumption increased from 6.5 to 11.6 ml O2 X min-1 X kg-1 when potassium exceeded 6 mEq/l; lactate did not increase.
Positive_regulation (increased) of MHS associated with malignant hyperthermia
14) Confidence 0.31 Published 1986 Journal Anesthesiology Section Abstract Doc Link 3079972 Disease Relevance 1.37 Pain Relevance 0.09
Cyclic-ADP-ribose (cADPR) is a naturally occurring nucleotide implicated in the regulation of the gating properties of the ryanodine channel, in fact cADPR may be a second messenger that activates the ryanodine receptor.
Positive_regulation (activates) of ryanodine receptor
15) Confidence 0.30 Published 2002 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 12413485 Disease Relevance 0.07 Pain Relevance 0.07
Caffeine sensitizes RyR so that low nanomolar concentrations of cytosolic calcium activate RyR leading to calcium efflux into the cytoplasm [2].
Positive_regulation (activate) of RyR
16) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2525814 Disease Relevance 0 Pain Relevance 0.03
Ca2+ uptake capacity and SERCA activity was found to be significantly increased in MHS pigs [20] and in HEK-293 cells transfected by MH mutants [21] but was described to be lower in MHS muscle compared to normal human skeletal muscle [22].
Positive_regulation (increased) of MHS in skeletal muscle associated with malignant hyperthermia
17) Confidence 0.15 Published 2005 Journal BMC Anesthesiol Section Body Doc Link PMC1175794 Disease Relevance 0.49 Pain Relevance 0.07
CONCLUSIONS: Bupivacaine's ability to enhance Ca2+ release channel-ryanodine receptor activity of skeletal muscle sarcoplasmic reticulum most likely contributes to the myotoxicity of this local anesthetic.
Spec (likely) Positive_regulation (enhance) of channel-ryanodine receptor in skeletal muscle
18) Confidence 0.11 Published 1999 Journal Anesthesiology Section Body Doc Link 10078686 Disease Relevance 0.12 Pain Relevance 0
In the endothelial endoplasmic reticulum, the ryanodine receptor activity is stimulated by caffeine, concentrations of Ca2+, and adenine nucleotides.
Positive_regulation (stimulated) of ryanodine receptor in reticulum
19) Confidence 0.06 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC3003984 Disease Relevance 0 Pain Relevance 0.04
Additional interactions between Ca2+, Se, and selenoproteins can occur through the ryanodine receptor as shown in Figure 14.
Positive_regulation (occur) of ryanodine receptor
20) Confidence 0.06 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1820789 Disease Relevance 0.32 Pain Relevance 0

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