INT156484

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 6.78
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoa1) transport (Apoa1) extracellular space (Apoa1)
extracellular region (Apoa1) nucleus (Apoa1) enzyme binding (Apoa1)
Anatomy Link Frequency
duct 1
T lymphocytes 1
Apoa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 1 98.64 Very High Very High Very High
Multiple sclerosis 96 98.20 Very High Very High Very High
cytokine 16 95.88 Very High Very High Very High
Bile 2 95.76 Very High Very High Very High
rheumatoid arthritis 34 93.84 High High
Inflammation 28 92.36 High High
imagery 14 88.04 High High
fibrosis 50 86.64 High High
alcohol 12 31.68 Quite Low
Central nervous system 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 26 100.00 Very High Very High Very High
Pancreatic Cancer 4 99.76 Very High Very High Very High
Pancreatitis 2 98.64 Very High Very High Very High
Demyelinating Disease 118 98.20 Very High Very High Very High
Insulin Resistance 8 98.12 Very High Very High Very High
Obesity 30 96.92 Very High Very High Very High
Cholestasis 1 95.76 Very High Very High Very High
Increased Venous Pressure Under Development 2 94.88 High High
Jaundice 1 94.68 High High
Systemic Lupus Erythematosus 38 94.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ApoA-I bound the stimulating factor at the surface of T lymphocytes, hampered the binding of stimulated T lymphocytes with its specific receptor at monocyte surface, thus inhibited the production of pro-inflammatory cytokines including TNF-?
ApoA-I Binding (bound) of in T lymphocytes associated with inflammation and cytokine
1) Confidence 0.47 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2860353 Disease Relevance 2.08 Pain Relevance 0.75
In this study, we found age at onset have a significantly effect on serum apoA-I levels in MS patients relative to other lipid indicators (TG, HDL-C, LDL-C, apoB100), which show that apoA-I is not only associated with serum lipid metabolism, but with the pathogenesis of MS.
apoA-I Binding (associated) of associated with multiple sclerosis and disorder of lipid metabolism
2) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2860353 Disease Relevance 1.87 Pain Relevance 0.46
Comparing patients with pancreatic cancer, chronic pancreatitis or biliary duct obstruction, we observed that the plasma levels of apolipoprotein A1, transthyretin, and apolipoprotein E, when examined in isolation, were each associated with pancreatic cancer.
apolipoprotein A1 Binding (associated) of in duct associated with pancreatic cancer, chronic pancreatitis and disorder of lipid metabolism
3) Confidence 0.04 Published 2009 Journal J. Proteome Res. Section Abstract Doc Link 19055369 Disease Relevance 1.19 Pain Relevance 0.19
ApoA1 is highly associated with HDL-cholesterol and a negative association was also expected with steatosis [29].
ApoA1 Binding (associated) of associated with disorder of lipid metabolism
4) Confidence 0.04 Published 2005 Journal Comp Hepatol Section Body Doc Link PMC1327680 Disease Relevance 0.67 Pain Relevance 0.19
2-macroglobulin (A2M), apolipoprotein A-I (ApoA1), haptoglobin, total bilirubin, GGT, cholesterol, triglycerides, glucose, age, gender and BMI.
ApoA1 Binding (haptoglobin) of associated with obesity and disorder of lipid metabolism
5) Confidence 0.04 Published 2005 Journal Comp Hepatol Section Body Doc Link PMC1327680 Disease Relevance 0.96 Pain Relevance 0.04

General Comments

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