INT156488

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 46
Total Number 48
Disease Relevance 15.64
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
brain 4
cleavage 2
neurite 2
other parts 1
PNS 1
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 220 98.80 Very High Very High Very High
Peripheral nervous system 196 98.48 Very High Very High Very High
cerebral cortex 52 91.04 High High
cINOD 265 88.04 High High
Hippocampus 155 87.12 High High
sodium channel 112 86.80 High High
Nav1.1 84 85.92 High High
Action potential 40 82.40 Quite High
Inflammation 518 81.60 Quite High
Inflammatory response 84 78.68 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1530 100.00 Very High Very High Very High
Disease 3872 99.98 Very High Very High Very High
Alzheimer's Dementia 1202 99.52 Very High Very High Very High
Stress 1203 99.24 Very High Very High Very High
Death 327 98.72 Very High Very High Very High
Apoptosis 500 98.20 Very High Very High Very High
Amyloid Plaque 473 95.92 Very High Very High Very High
Amyloidosis 63 95.80 Very High Very High Very High
Hypoxia 634 95.36 Very High Very High Very High
Cognitive Disorder 721 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, BACE1 interacts with a number of other protein moieties, many of which are involved in protein trafficking, and so alterations in the level of these proteins may in turn affect BACE1 levels, subcellular localization and/or activity.
BACE1 Binding (interacts) of
1) Confidence 0.48 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.27 Pain Relevance 0
The ACDL of BACE1 binds to members of the Golgi-localized ?
BACE1 Binding (binds) of
2) Confidence 0.48 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0 Pain Relevance 0
-secretase processing of APP is modulated by the interaction of BACE1 with neurite growth inhibitor NOGO, a component of myelin, and a member of the reticulon family of proteins [112].
BACE1 Binding (interaction) of in neurite
3) Confidence 0.48 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.07 Pain Relevance 0.11
Indeed, BACE1 interacts with all members of the reticulon protein family [112, 113].
BACE1 Binding (interacts) of
4) Confidence 0.48 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.06 Pain Relevance 0.18
Interestingly, certain molecules have been shown to inhibit the BACE1-APP interaction and thus reduce ?
BACE1 Binding (interaction) of
5) Confidence 0.48 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.08 Pain Relevance 0
Conversely, certain molecules have been shown to inhibit the BACE1-APP interaction and thus reduce ?
BACE1 Binding (interaction) of
6) Confidence 0.47 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.09 Pain Relevance 0
Some studies found that BACE1 can interact with reticulon/Nogo proteins, whose increased expression can block BACE1 in the ER with a neutral pH environment and thus inhibit BACE1 activity in A?
BACE1 Binding (interact) of
7) Confidence 0.46 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0 Pain Relevance 0
Of interest are data that indicate that a decrease in cellular cholesterol levels by the cholesterol lowering statin drugs, prevented BACE1 palmitoylation in vitro, which consequently prevented BACE1 dimerization, facilitated a change in the subcellular location of the enzyme and a subsequent reduction in A?
BACE1 Binding (dimerization) of
8) Confidence 0.41 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.06 Pain Relevance 0
The association of elevated BACE1 with overt amyloid pathology, in both Tg mouse models of AD and AD brain, indicates that A?
BACE1 Binding (association) of in brain associated with targeted disruption and alzheimer's dementia
9) Confidence 0.41 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.82 Pain Relevance 0.08
The beta-site APP-cleaving enzyme 1 (BACE1) is widely known for its pivotal role in the amyloidogenic pathway leading to Alzheimer's disease.
BACE1 Binding (known) of associated with disease
10) Confidence 0.37 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19056495 Disease Relevance 0.10 Pain Relevance 0.21
The beta-site APP-cleaving enzyme 1 (BACE1) is widely known for its pivotal role in the amyloidogenic pathway leading to Alzheimer's disease.
beta-site APP-cleaving enzyme 1 Binding (known) of associated with disease
11) Confidence 0.37 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19056495 Disease Relevance 0.10 Pain Relevance 0.21
Furthermore, not only BACE1 mRNA but also phosphorylation of the translation initiation factor eIF2?
BACE1 mRNA Binding (only) of
12) Confidence 0.37 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC2988063 Disease Relevance 1.24 Pain Relevance 0.17
-secretase, which generates an ?
secretase Binding (generates) of
13) Confidence 0.37 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.12 Pain Relevance 0.31
Importantly, data generated from BACE1 null mice showed that the absence of BACE1 was associated with hypomyelination of both CNS and PNS axons.
BACE1 Binding (associated) of in PNS associated with peripheral nervous system and central nervous system
14) Confidence 0.37 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.09 Pain Relevance 0.30
Data generated from BACE1-deficient mouse models was unanimous in demonstrating that ?
BACE1 Binding (generated) of
15) Confidence 0.37 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.25 Pain Relevance 0
-secretase complex are essential for A?
secretase Binding (complex) of
16) Confidence 0.37 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.09 Pain Relevance 0
Cleavage of IL-1R2 by both BACE enzymes occurred at sites that agreed well with the known cleavage specificity of BACE1 and BACE2 and led to the generation of CTF that were similar to those generated by ?
BACE1 Binding (specificity) of in cleavage
17) Confidence 0.37 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.17 Pain Relevance 0.04
-secretase activity, thus reconciling the paradoxically high BACE1 mRNA levels with the low ?
BACE1 mRNA Binding (reconciling) of
18) Confidence 0.37 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0 Pain Relevance 0
Data generated from BACE1-deficient mouse models was unanimous in demonstrating that ?
BACE1 Binding (generated) of
19) Confidence 0.37 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.44 Pain Relevance 0
Cleavage of IL-1R2 by both BACE enzymes occurred at sites that agreed well with the known cleavage specificity of BACE1 and BACE2 and led to the generation of CTF that were similar to those generated by ?
BACE1 Binding (specificity) of in cleavage
20) Confidence 0.37 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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