INT156489

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2011
Negated 6
Speculated 8
Reported most in Body
Documents 67
Total Number 76
Disease Relevance 41.07
Pain Relevance 7.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
brain 27
neurons 8
hippocampus 6
cleavage 4
neuronal 2
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.2 34 100.00 Very High Very High Very High
Hippocampus 468 99.80 Very High Very High Very High
Inflammation 621 99.56 Very High Very High Very High
Nav1.1 97 97.64 Very High Very High Very High
ischemia 306 97.60 Very High Very High Very High
sodium channel 164 95.04 Very High Very High Very High
cINOD 286 93.72 High High
Neuronal excitability 57 89.16 High High
agonist 102 89.08 High High
glial activation 61 89.00 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 2255 100.00 Very High Very High Very High
Amyloid Plaque 646 100.00 Very High Very High Very High
Stress 1965 99.98 Very High Very High Very High
Toxicity 110 99.90 Very High Very High Very High
Apoptosis 640 99.74 Very High Very High Very High
Hypoxia 813 99.68 Very High Very High Very High
Brain Injury 369 99.60 Very High Very High Very High
INFLAMMATION 803 99.56 Very High Very High Very High
Disease 4733 99.48 Very High Very High Very High
Alzheimer's Dementia 1761 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoblot analysis of hippocampal homogenates from male (Figure 3A) and female (Figure 3B) mice demonstrated that 5-day exposure to restraint stress did not change BACE1 levels in male 5XFAD mice (Figure 3C), whereas it increased BACE1 expression in female 5XFAD mice (Figure 3D).
Positive_regulation (increased) of Gene_expression (expression) of BACE1 associated with stress
1) Confidence 0.69 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.66 Pain Relevance 0.14
Collectively, 5-day exposure to restraint stress induced a marked increase of C99 levels, which was accompanied by significant elevations in both BACE1 and APP expression, specifically in the hippocampus of female 5XFAD mice consistent with the significantly increased A?
Positive_regulation (elevations) of Gene_expression (expression) of BACE1 in hippocampus associated with stress and hippocampus
2) Confidence 0.69 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.58 Pain Relevance 0.17
Importantly, we found that BACE1 expression was elevated specifically in the hippocampus of stressed female 5XFAD mice in accordance with increased levels of A?
Positive_regulation (elevated) of Gene_expression (expression) of BACE1 in hippocampus associated with hippocampus
3) Confidence 0.69 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 1.02 Pain Relevance 0.08
Moreover, increased BACE1 expression facilitated an enhancement of ?
Positive_regulation (increased) of Gene_expression (expression) of BACE1
4) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.30 Pain Relevance 0
increases BACE1 expression and activity [144].
Positive_regulation (increases) of Gene_expression (expression) of BACE1
5) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.07 Pain Relevance 0
In addition to inflammation other conditions may cause BACE1 expression to increase in the brain, including oxidative stress, TBI, hypoxia and ischemia.


Positive_regulation (increase) of Gene_expression (expression) of BACE1 in brain associated with stress, inflammation, hypoxia, ischemia and brain injury
6) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.18 Pain Relevance 0.40
In addition to inflammation other conditions may cause BACE1 expression to increase in the brain, including oxidative stress, TBI, hypoxia and ischemia.


Spec (may) Positive_regulation (cause) of Gene_expression (expression) of BACE1 in brain associated with stress, inflammation, hypoxia, ischemia and brain injury
7) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.18 Pain Relevance 0.40
While Zuchner reported that selective stimulation of M1 muscarininc acetylcholine receptors (mAChRs) increased BACE1 protein expression, with the activation of M2 mAChRs having opposing effects on the level of BACE1 protein [209], Caccamo and colleagues reported an impressive and almost complete inhibition of BACE1 protein expression following treatment of the 3xTg-AD model with a selective M1 muscarinic agonist [210].
Positive_regulation (increased) of Gene_expression (expression) of BACE1 protein associated with agonist and disease
8) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.33 Pain Relevance 0.08
Interestingly, the HNE-dependent upregulation of BACE1 expression observed in vitro, appeared to be dependent on the activation of c-jun N-terminal kinases (JNK) and p38MAPK [170].
Positive_regulation (upregulation) of Gene_expression (expression) of BACE1
9) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.46 Pain Relevance 0
Glia out-number neurons by ~10:1, so even a slight increase in glial BACE1 expression might contribute substantially to cerebral A?
Positive_regulation (increase) of Gene_expression (expression) of BACE1 in neurons
10) Confidence 0.69 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.64 Pain Relevance 0.62
In addition to inflammation other conditions may cause BACE1 expression to increase in the brain, including oxidative stress, traumatic brain injury (TBI), hypoxia and ischemia.
Spec (may) Positive_regulation (cause) of Gene_expression (expression) of BACE1 in brain associated with stress, inflammation, hypoxia, ischemia and brain injury
11) Confidence 0.69 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.72 Pain Relevance 0.15
Moreover, increased BACE1 expression facilitated an enhancement of ?
Positive_regulation (increased) of Gene_expression (expression) of BACE1
12) Confidence 0.69 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.14 Pain Relevance 0
In addition to inflammation other conditions may cause BACE1 expression to increase in the brain, including oxidative stress, traumatic brain injury (TBI), hypoxia and ischemia.
Positive_regulation (increase) of Gene_expression (expression) of BACE1 in brain associated with stress, inflammation, hypoxia, ischemia and brain injury
13) Confidence 0.69 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.72 Pain Relevance 0.15
A molecular basis for the observed elevation of BACE1 expression during hypoxia has been recently provided by the identification of a functional HRE in the BACE1 gene promoter [214,224].
Positive_regulation (elevation) of Gene_expression (expression) of BACE1 associated with hypoxia
14) Confidence 0.69 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 1.31 Pain Relevance 0
Interestingly, BACE1 mRNA expression is increased in APP Tg mice maintained under hypoxic conditions, and the hypoxia appeared to potentiate the memory deficits observed in these mice [214].
Positive_regulation (increased) of Gene_expression (expression) of BACE1 mRNA associated with targeted disruption and hypoxia
15) Confidence 0.69 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.91 Pain Relevance 0
42 appeared to exert extremely potent effects and caused enhanced BACE1 expression and activity [215].
Positive_regulation (enhanced) of Gene_expression (expression) of BACE1
16) Confidence 0.69 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.44 Pain Relevance 0
increases BACE1 expression and activity [168].
Positive_regulation (increases) of Gene_expression (expression) of BACE1
17) Confidence 0.69 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.38 Pain Relevance 0.04
-mediated activation of JAK2 and ERK1/2, STAT1 binds to BACE1 promoter region to increase BACE1 protein expression in astrocytes [91].
Positive_regulation (increase) of Gene_expression (expression) of BACE1 protein in astrocytes
18) Confidence 0.60 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.77 Pain Relevance 0.38
Meanwhile, BACE1 levels in 15–18-month-old 5XFAD mice were significantly increased up to ?
Positive_regulation (increased) of Gene_expression (levels) of BACE1
19) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.09 Pain Relevance 0
Notably, evidence is accumulating that BACE1 expression and activity levels are significantly elevated in sporadic AD brains, which is considered a crucial contributing factor in the pathogenesis of this enigmatic disease [23], [24], [25], [26], [27].
Positive_regulation (elevated) of Gene_expression (expression) of BACE1 in brains associated with disease
20) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 1.11 Pain Relevance 0

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