INT156501

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 10.26
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MAGEA1) nucleus (MAGEA1) cytoplasm (MAGEA1)
Anatomy Link Frequency
blood 2
testis 1
lung 1
MAGEA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 79.92 Quite High
cytokine 41 5.00 Very Low Very Low Very Low
Pain 13 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
positron emission tomography 3 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 43 100.00 Very High Very High Very High
Cancer 460 99.98 Very High Very High Very High
Papillomavirus Infection 33 99.80 Very High Very High Very High
Melanoma 12 99.38 Very High Very High Very High
Lung Cancer 20 98.76 Very High Very High Very High
Disease 118 97.92 Very High Very High Very High
Non-small-cell Lung Cancer 75 97.80 Very High Very High Very High
Testicular Cancer 2 95.28 Very High Very High Very High
Immunotherapy Of Cancer 23 89.00 High High
Autoimmune Disease 5 85.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
De Smet et al., first showed a link between genomic DNA hypomethylation and MAGE-1 gene expression [39], and subsequent studies demonstrated direct correlation between demethylation of CpG at the promoter of several cancer testis antigen coding genes with their expression [40-43].
Gene_expression (expression) of MAGE in testis associated with testicular cancer
1) Confidence 0.18 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.68 Pain Relevance 0
Characterization of these cells using confocal microscopy, FACs analysis and western blotting showed that they expressed melanoma-associated antigens; Melan-A, MAGE-1, and MAGE-3, and PCNA expression was higher in fast-proliferating isolates.
Gene_expression (expression) of MAGE-1 associated with melanoma
2) Confidence 0.12 Published 2009 Journal In Vitro Cell. Dev. Biol. Anim. Section Abstract Doc Link 19057970 Disease Relevance 1.02 Pain Relevance 0.08
To produce the first type, an adjuvant is combined with 1 or more peptides/proteins commonly expressed on HNSCC such as p53, MAGE, or HPV.
Gene_expression (expressed) of MAGE associated with papillomavirus infection
3) Confidence 0.05 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2723756 Disease Relevance 0.93 Pain Relevance 0
For example, up to 71% of HNSCCs express antigens from at least 1 of 6 melanoma antigen genes (MAGEs) [57], notably MAGE-1 and MAGE-3 [58].
Gene_expression (express) of MAGE associated with skin cancer
4) Confidence 0.04 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2723756 Disease Relevance 1.48 Pain Relevance 0
For example, up to 71% of HNSCCs express antigens from at least 1 of 6 melanoma antigen genes (MAGEs) [57], notably MAGE-1 and MAGE-3 [58].
Gene_expression (express) of MAGE associated with skin cancer
5) Confidence 0.04 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2723756 Disease Relevance 1.48 Pain Relevance 0
To avoid performing repeat biopsies, this was achieved by detecting MAGE A3 or MAGE A4 expression in peripheral blood tumor cells by RT-PCR using established methods.
Gene_expression (expression) of MAGE in blood associated with cancer
6) Confidence 0.02 Published 2005 Journal J Transl Med Section Body Doc Link PMC551593 Disease Relevance 0.95 Pain Relevance 0
Among the most frequently expressed across many malignancies are the MAGE antigens, originally described in melanoma, but expressed by other tumors including non-small cell lung cancer (NSCLC) [1-3].
Gene_expression (expressed) of MAGE in lung associated with lung cancer, non-small-cell lung cancer, cancer and skin cancer
7) Confidence 0.02 Published 2005 Journal J Transl Med Section Body Doc Link PMC551593 Disease Relevance 0.92 Pain Relevance 0
In addition, patients were required to have tumor expressing MAGE A3 or MAGE A4.
Gene_expression (expressing) of MAGE associated with cancer
8) Confidence 0.02 Published 2005 Journal J Transl Med Section Body Doc Link PMC551593 Disease Relevance 0.93 Pain Relevance 0
To avoid performing repeat biopsies, this was achieved by detecting MAGE A3 or MAGE A4 expression in peripheral blood tumor cells by RT-PCR using established methods.
Gene_expression (expression) of MAGE in blood associated with cancer
9) Confidence 0.02 Published 2005 Journal J Transl Med Section Body Doc Link PMC551593 Disease Relevance 0.95 Pain Relevance 0
In addition, patients were required to have tumor expressing MAGE A3 or MAGE A4.
Gene_expression (expressing) of MAGE associated with cancer
10) Confidence 0.02 Published 2005 Journal J Transl Med Section Body Doc Link PMC551593 Disease Relevance 0.92 Pain Relevance 0

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