INT156509

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.93
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
TMJ 4
Il6 (Rattus norvegicus)
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Snapping jaw 18 100.00 Very High Very High Very High
Inflammation 16 100.00 Very High Very High Very High
nMDA receptor 12 100.00 Very High Very High Very High
Pain 8 98.24 Very High Very High Very High
Lasting pain 2 82.96 Quite High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 18 100.00 Very High Very High Very High
INFLAMMATION 10 100.00 Very High Very High Very High
Pain 10 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we examined the hypothesis that the upregulation of the NR1 subunit of the NMDA receptor (NR1) in the trigeminal subnucleus caudalis (Sp5c) following inflammation of the temporomandibular joint (TMJ) region would be regulated by interleukin-6 (IL-6) and the nuclear factor-kappa B (NF-kappaB).
IL-6 Regulation (regulated) of Spec (examined) Positive_regulation (upregulation) of NR1 in TMJ associated with snapping jaw, inflammation and nmda receptor
1) Confidence 0.28 Published 2009 Journal Pain Section Abstract Doc Link 19058915 Disease Relevance 0.97 Pain Relevance 0.97
Here, we examined the hypothesis that the upregulation of the NR1 subunit of the NMDA receptor (NR1) in the trigeminal subnucleus caudalis (Sp5c) following inflammation of the temporomandibular joint (TMJ) region would be regulated by interleukin-6 (IL-6) and the nuclear factor-kappa B (NF-kappaB).
interleukin-6 Regulation (regulated) of Spec (examined) Positive_regulation (upregulation) of NR1 in TMJ associated with snapping jaw, inflammation and nmda receptor
2) Confidence 0.28 Published 2009 Journal Pain Section Abstract Doc Link 19058915 Disease Relevance 0.96 Pain Relevance 0.96

General Comments

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