INT156517

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Context Info
Confidence 0.38
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.53
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (CNR1) cytoskeleton (FAAH) plasma membrane (CNR1)
cytoplasm (FAAH) response to stress (CNR1) signal transducer activity (CNR1)
Anatomy Link Frequency
osteoclasts 2
CNR1 (Homo sapiens)
FAAH (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid 13 99.98 Very High Very High Very High
Endocannabinoid 26 91.72 High High
agonist 4 78.40 Quite High
palliative 1 77.96 Quite High
Cannabinoid receptor 2 32.24 Quite Low
qutenza 2 25.00 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 51 100.00 Very High Very High Very High
Cancer 77 99.76 Very High Very High Very High
Hypercalcemia 2 94.20 High High
Disease 26 82.36 Quite High
Malignant Neoplastic Disease 12 57.64 Quite High
Overactive Bladder 1 52.16 Quite High
Death 7 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low
Pancreatic Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we examined the co-expression of the transient receptor potential vanilloid type 1 (TRPV1) and the cannabinoid CB1/CB2 receptors together with N-acylphosphatidylethanolamine-hydrolizing phospholipase D (NAPE-PLD) and fatty acid amide hydrolase (FAAH), the two enzymes responsible of the synthesis and catabolism of anandamide respectively, in human osteoclasts.
CB1 Binding (receptors) of FAAH in osteoclasts associated with cannabinoid
1) Confidence 0.38 Published 2009 Journal Bone Section Abstract Doc Link 19059369 Disease Relevance 0.09 Pain Relevance 0.23
Here, we examined the co-expression of the transient receptor potential vanilloid type 1 (TRPV1) and the cannabinoid CB1/CB2 receptors together with N-acylphosphatidylethanolamine-hydrolizing phospholipase D (NAPE-PLD) and fatty acid amide hydrolase (FAAH), the two enzymes responsible of the synthesis and catabolism of anandamide respectively, in human osteoclasts.
CB1 Binding (receptors) of fatty acid amide hydrolase in osteoclasts associated with cannabinoid
2) Confidence 0.38 Published 2009 Journal Bone Section Abstract Doc Link 19059369 Disease Relevance 0.09 Pain Relevance 0.23
Tumour epithelial FAAH-IR is associated with prostate cancer severity and outcome at mid-range, but not high, CB1IR scores.
CB1IR Binding (associated) of FAAH associated with cancer and prostate cancer
3) Confidence 0.22 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2924377 Disease Relevance 1.34 Pain Relevance 0.08

General Comments

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